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International Journal of Pharmacology
  Year: 2017 | Volume: 13 | Issue: 3 | Page No.: 292-302
DOI: 10.3923/ijp.2017.292.302
 
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Enhancement of Efficacy and Reduced Toxicity of Cisplatin Through Self Nanoemulsifying Drug Delivery System (SNEDDS)

Abdel-Moneim M. Osman , Huda M. Al-Kreathy, Amal Al-Zahrani, Osama A. Ahmed, Wafaa S. Ramadan, Mohamed F. ElShal, Samir E. Al-Harthi, Ahmed S. Ali and Lateef M. Khan

Abstract:
Background: Cisplatin is a potent antineoplastic agent with high therapeutic efficacy against many kinds of tumors. Its clinical use limited by its numerous side-effects, especially nephrotoxicity. Objective: The aim of this study was directed to formulate cisplatin self-nanoemulsifying drug delivery system (cisplatin-SNEDDS) as an attempt to improve the therapeutics activity and reduction of cisplatin toxicity. Materials and Methods: To evaluate these effects the cytotoxic activity of cisplatin-SNEDDS on the growth of Ehrlich Ascites Carcinoma (EAC) was assessed by determine the survival time of tumor-bearing mice, cisplatin cellular uptake, apoptosis induction, cell cycle distribution and renal function after treatment with cisplatin-SNDDS, compared with free cisplatin. Results: Free cisplatin increased the mean survival time of tumor bearing mice to 36 days compared with tumor bearing control mice while treatment of tumor bearing mice with cisplatin-SNEDDS showed a significant increase in their mean survival time to 44.30 days. Also, cisplatin-SNEDDS (7.5 mg kg–1) significantly accumulated the cells in sub-G1 and dramatically increased the percentage of early apoptotic cells in comparison to free cisplatin. Treatment with cisplatin-SNEDD retained rat’s serum urea, creatinine and TAC levels to normal level and significantly increase the reduced glutathione in kidney homogenate compared to animals treated with free cisplatin. Conclusion: The SNEDDS enhanced the cytotoxic activity of cisplatin against the growth of EAC in vivo and protect against its nephrotoxicity.
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How to cite this article:

Abdel-Moneim M. Osman, Huda M. Al-Kreathy, Amal Al-Zahrani, Osama A. Ahmed, Wafaa S. Ramadan, Mohamed F. ElShal, Samir E. Al-Harthi, Ahmed S. Ali and Lateef M. Khan, 2017. Enhancement of Efficacy and Reduced Toxicity of Cisplatin Through Self Nanoemulsifying Drug Delivery System (SNEDDS). International Journal of Pharmacology, 13: 292-302.

DOI: 10.3923/ijp.2017.292.302

URL: https://scialert.net/abstract/?doi=ijp.2017.292.302

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