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International Journal of Pharmacology
  Year: 2017 | Volume: 13 | Issue: 3 | Page No.: 237-246
DOI: 10.3923/ijp.2017.237.246
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Aspects of Medicinal Activities of the Stem Bark Extracts of Curtisia dentata (Burm. F.)

Olubunmi Abosede Wintola and Anthony Jide Afolayan

Background: Dysentery is a chronic disease causing intestinal inflammation as a result of severe diarrhoea with mucus or blood in the faeces. This is caused either by infectious or non-infectious agents and the severity ranges from asymptomatic to severe dehydration resulting into death. Methodology: Phytochemical, antioxidant and antimicrobial analyses were carried out using standard methods and the crude extracts were screened against 12 bacteria strains. Agar well diffusion and broth micro-dilution techniques were used to determine the diameters of zone of inhibition and the Minimum Inhibition Concentrations (MICs), respectively. Results: Phytochemical assay revealed the presence of high content of flavonoids, total phenol and tannins, low equivalent quantity of saponins and proanthocyanidin and very low alkaloids. Antioxidant activity showed high nitric oxide, low ferric reducing activities, moderate/low DPPH and ABTS scavenging activities of the plant. The degree of inhibitions varied significantly with different solvents used. Curtisia dentata activity against all the tested bacterial demonstrated an inhibition mean zone diameter of 10-25 mm. The MIC of the acetone extract ranged from >5 to 0.01 mg mL–1 and was active against 10 out of the 12 bacteria isolates with Escherichia coli (20±1.1) being the most susceptible organism. Conclusion: This study provides scientific evidence for ethnomedicinal uses of Curtisia dentata stem bark as a good source of free radical scavenging and antimicrobial agents. This appreciably justifies the ethnomedicinal importance of the plant.
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How to cite this article:

Olubunmi Abosede Wintola and Anthony Jide Afolayan, 2017. Aspects of Medicinal Activities of the Stem Bark Extracts of Curtisia dentata (Burm. F.). International Journal of Pharmacology, 13: 237-246.

DOI: 10.3923/ijp.2017.237.246






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