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International Journal of Pharmacology
  Year: 2016 | Volume: 12 | Issue: 2 | Page No.: 86-91
DOI: 10.3923/ijp.2016.86.91
 
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A Potent Cyclooxygenase-2 Inhibitor for Synthesized Pyrimidine and Thiazolopyrimidine Derivatives
Abd El-Galil E. Amr, Mohamed A. Al-Omar and Mohamed M. Abdalla

Abstract:
Ten pyridine and pyrimidine and thiazolopyrimidine derivatives (1-10) were synthesized and screened as analgesic, anticonvulsant and antiparkinsonian agent beforeTen pyridine and pyrimidine and thiazolopyrimidine derivatives (1-10) were synthesized and screened as analgesic, anticonvulsant and antiparkinsonian agent before. Herein, all the target compounds showed anti-inflammatory activity. The active compounds showed selective inhibitory activity towards COX-2 enzyme as revealed by the in vitro enzymatic assay. All the tested compounds proved to have superior gastrointestinal (GI) safety profiles as compared to indomethacin, when tested for their ulcerogenic effects.

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How to cite this article:

Abd El-Galil E. Amr, Mohamed A. Al-Omar and Mohamed M. Abdalla, 2016. A Potent Cyclooxygenase-2 Inhibitor for Synthesized Pyrimidine and Thiazolopyrimidine Derivatives. International Journal of Pharmacology, 12: 86-91.

DOI: 10.3923/ijp.2016.86.91

URL: https://scialert.net/abstract/?doi=ijp.2016.86.91

 
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