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International Journal of Pharmacology

Year: 2016 | Volume: 12 | Issue: 8 | Page No.: 801-811
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Authors

Khalid Abd El Ghany

Ragaa A. Hamouda

Hoda Mahrous

Hoda Mahrous

Ekbal Abd Elhafez

Fath Allah H. Ahmed

Hanafy A. Hamza

Keywords

Background: Lactic Acid Bacteria (LAB) have great therapeutic and nutritional benefits. Among these are: Improved nutritional value of food, control of intestinal infections, improved digestion of lactose, immune modulator effect, control of some types of cancer and control of serum glucose level. Objective: The aim of this study was carried out to evaluate the therapeutic effect of β-glucan extracted from LAB was isolated from different food sources in Egypt. Materials and Methods: The isolation was performed from local Egyptian boza, cider, cheese and yoghurt. Only seven species from 27 was identified as LAB. Only one showed to produce β-glucan and identified by VITEC® 2 as Pediococcus parvulus . The optimization of isolate growth was examined in different temperature, pH and media. Results: The study revealed that the optimum temperature was 37°C, pH was 6 and the most selective medium for growth was Pediococcus selective medium (PSM). Beta-glucan production was assessed by FT-IR analysis, HPLC and HNMR spectroscopy. The therapeutic effect of Pediococcus parvulus β-glucan as antioxidant against DPPH was more significant, cholesterol lowering effect of β-glucan gave valuable results compared to simvastatin drug, the antibacterial effect and control of cancer in vitro against Ehrlich Ascites Carcinoma (EAC) were also gave valuable results. Conclusion: The extracted β-glucan from Egyptian Pediococcus parvulus had different therapeutic effect in vitro including, antioxidative properties, antimicrobial, control of cancer and cholesterol lowering effect.
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How to cite this article

Khalid Abd El Ghany, Ragaa A. Hamouda, Hoda Mahrous, Ekbal Abd Elhafez, Fath Allah H. Ahmed and Hanafy A. Hamza, 2016. Description of Isolated LAB Producing β-glucan from Egyptian Sources and Evaluation of its Therapeutic Effect. International Journal of Pharmacology, 12: 801-811.

DOI: 10.3923/ijp.2016.801.811

URL: https://scialert.net/abstract/?doi=ijp.2016.801.811

Comments

Omar Shaheen Reply

Good paper

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