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International Journal of Pharmacology

Year: 2016 | Volume: 12 | Issue: 7 | Page No.: 701-710
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Authors

Franklin Uangbaoje Ohikhena

Olubunmi Abosede Wintola

Anthony Jide Afolayan

Keywords

Research Article

Toxicity Assessment of Different Solvent Extracts of the Medicinal Plant, Phragmanthera capitata (Sprengel) Balle on Brine Shrimp (Artemia salina)

Franklin Uangbaoje Ohikhena, Olubunmi Abosede Wintola and Anthony Jide Afolayan
Background: There has been a surge in the use of medicinal plants in the past decades; hence, the screening of potential cytotoxic compounds is of utmost importance to guarantee their safe use in alternative medicine. Different solvent extracts of the leaves of Phragmanthera capitata (Sprengel) Balle, a parasitic mistletoe growing on rubber tree were evaluated for possible toxicity. Methodology: Brine shrimp (Artemia salina ) hatchability (based on the Minimum Inhibitory Concentration (MIC50) of the extracts to inhibit 50% hatching of the cysts) and lethality (based on the Lethal Concentration (LC50) of the extracts to kill 50% of the hatched cysts (nauplii)) assays were employed to evaluate the possible toxicity of the species. Results: Lowest hatching percentage was recorded in the ethanolic extract (34.40%) with an MIC50 value of 0.14 mg mL–1 and the highest hatching success was observed in the aqueous extract (59.33%) with an MIC50 value of 0.59 mg mL–1. All the extracts hatching success were significantly higher than the positive control (Amoxicillin) (p<0.05). The LC50 for the lethality assay in all the solvent extracts was greater than 1 mg mL–1. Conclusion: Based on Meyer’s toxicity index, LC50>1 mg mL–1 were considered non-toxic hence, all the solvent extracts tested showed that they were not toxic and can be further explored for the development of plant-based pharmaceuticals drugs. Further in vivo and cell lines cytotoxicity test is recommended to substantiate these findings.
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How to cite this article

Franklin Uangbaoje Ohikhena, Olubunmi Abosede Wintola and Anthony Jide Afolayan, 2016. Toxicity Assessment of Different Solvent Extracts of the Medicinal Plant, Phragmanthera capitata (Sprengel) Balle on Brine Shrimp (Artemia salina). International Journal of Pharmacology, 12: 701-710.

DOI: 10.3923/ijp.2016.701.710

URL: https://scialert.net/abstract/?doi=ijp.2016.701.710

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