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International Journal of Pharmacology
  Year: 2016 | Volume: 12 | Issue: 2 | Page No.: 66-73
DOI: 10.3923/ijp.2016.66.73
 
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Monoamino Oxidase Inhibitors Activities of Some Synthesized 2,6-bis (Tetracarboxamide)-pyridine and Macrocyclic Octacarboxamide Derivatives
Abd El-Galil E Amr, Mohamed A. Al- Omar and Mohamed M. Abdalla

Abstract:
A series of chiral linear and macrocyclic bridged pyridines (1-8) has been prepared starting from pyridine-2,6-dicarbonyl dichloride and they screened as antimicrobial agents before. Screening of the compounds for their Inhibition of type A and type B monoamine oxidase activities in mitochondria preparation revealed that the tested compounds showed selective inhibition of type A monoamine oxidase activities in the following order 4a, 6, 5a, 3, 4b, 5b, 1, 4c, 7, 8 and 2, this confirmed by the in vivo tryptamine seizure potentiation model in rats. The tested compounds showed in vivo good pharmacokinetic and pharmacodynamic profiles.
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How to cite this article:

Abd El-Galil E Amr, Mohamed A. Al- Omar and Mohamed M. Abdalla, 2016. Monoamino Oxidase Inhibitors Activities of Some Synthesized 2,6-bis (Tetracarboxamide)-pyridine and Macrocyclic Octacarboxamide Derivatives. International Journal of Pharmacology, 12: 66-73.

DOI: 10.3923/ijp.2016.66.73

URL: https://scialert.net/abstract/?doi=ijp.2016.66.73

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