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International Journal of Pharmacology

Year: 2015 | Volume: 11 | Issue: 7 | Page No.: 821-827
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Authors

Yunus Ahmed

Zahira Yaakob

Parul Akhtar

Mahbubur Rahman

Faridul Islam

Keywords

Research Article

In vitro Antibacterial and in vivo Brine Shrimp Lethal Active Compounds Isolated from the Leaves of Saurauia roxburghii

Yunus Ahmed, Zahira Yaakob, Parul Akhtar, Mahbubur Rahman and Faridul Islam
Seven triterpenoids namely, ursolic acid (1) cis-3-O-p-hydroxycinnamoyl ursolic acid (2), trans-3-O-p-hydroxycinnamoyl ursolic acid (3), oleanolic acid (4), corosolic acid (5), maslinic acid (6) and β-amyrin (7) were isolated from the leaves of Saurauia roxburghii based on spectroscopic indication. Compounds 2, 3 and 4 were isolated from this plant for the first time. The LC50 for crude ethanol, n-hexane, chloroform, ethyl-acetate; column fractions H-13 of the crude n-hexane, C-19 of the crude chloroform and three pure compounds 1, 3 and 4 were found to be 12.59, 14.79, 14.06, 11.75, 10.96, 4.37, 6.92 and 11.88 μg mL–1, respectively. The crude ethanol extract exhibited good; n-hexane, chloroform, ethyl-acetate extracts exhibited moderate; five column fractions (H-13, C-15, C-19, E-18 and E-24) exhibited low to mild and three pure compounds (1, 3 and 4) presented moderate antibacterial activity against maximum of the tested bacteria.
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