Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2015 | Volume: 11 | Issue: 7 | Page No.: 821-827
DOI: 10.3923/ijp.2015.821.827
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

In vitro Antibacterial and in vivo Brine Shrimp Lethal Active Compounds Isolated from the Leaves of Saurauia roxburghii

Yunus Ahmed, Zahira Yaakob, Parul Akhtar, Mahbubur Rahman and Faridul Islam

Abstract:
Seven triterpenoids namely, ursolic acid (1) cis-3-O-p-hydroxycinnamoyl ursolic acid (2), trans-3-O-p-hydroxycinnamoyl ursolic acid (3), oleanolic acid (4), corosolic acid (5), maslinic acid (6) and β-amyrin (7) were isolated from the leaves of Saurauia roxburghii based on spectroscopic indication. Compounds 2, 3 and 4 were isolated from this plant for the first time. The LC50 for crude ethanol, n-hexane, chloroform, ethyl-acetate; column fractions H-13 of the crude n-hexane, C-19 of the crude chloroform and three pure compounds 1, 3 and 4 were found to be 12.59, 14.79, 14.06, 11.75, 10.96, 4.37, 6.92 and 11.88 μg mL–1, respectively. The crude ethanol extract exhibited good; n-hexane, chloroform, ethyl-acetate extracts exhibited moderate; five column fractions (H-13, C-15, C-19, E-18 and E-24) exhibited low to mild and three pure compounds (1, 3 and 4) presented moderate antibacterial activity against maximum of the tested bacteria.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Phytotoxic and Chemical Investigations of a Nigerian Medicinal Plant
How to cite this article:

Yunus Ahmed, Zahira Yaakob, Parul Akhtar, Mahbubur Rahman and Faridul Islam, 2015. In vitro Antibacterial and in vivo Brine Shrimp Lethal Active Compounds Isolated from the Leaves of Saurauia roxburghii. International Journal of Pharmacology, 11: 821-827.

DOI: 10.3923/ijp.2015.821.827

URL: https://scialert.net/abstract/?doi=ijp.2015.821.827

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 



Curve Bottom