Synthesized of Some Heterocyclic Systems and their Nucleoside of Potent Anti-inflammatory Activities

Research Article

Synthesized of Some Heterocyclic Systems and their Nucleoside of Potent Anti-inflammatory Activities

Said A. Said, Abd El-Galil E. Amr, Hassan A. El- Sayed, Mohamed A. Al- Omar and Mohamed M. Abdalla

Some of synthesized heterocyclic pyrimidine, pyrimidine, furopyridine derivatives and their nucleoside candidates (2-14) were previously prepared and were founded to have some aspects of structural similarity with many anti-inflammatory agents. Therefore, these agents were screened for this property. The evaluation of the anti-inflammatory activities was based on evaluation of the abilities of these compounds in protection against carrageenan-induced edema. The anti-inflammatory activities of the tested compounds further confirmed based on evaluation of the abilities of these compounds to inhibit plasma PGE2. These compounds showed potent anti-inflammatory activity with low toxicity (LD₅₀) comparable to Valdicoxib^® as reference anti-inflammatory drugs.

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Said A. Said, Abd El-Galil E. Amr, Hassan A. El- Sayed, Mohamed A. Al- Omar and Mohamed M. Abdalla, 2015. Synthesized of Some Heterocyclic Systems and their Nucleoside of Potent Anti-inflammatory Activities. International Journal of Pharmacology, 11: 502-507.

DOI: 10.3923/ijp.2015.502.507

URL: https://scialert.net/abstract/?doi=ijp.2015.502.507

International Journal of Pharmacology

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Authors

Said A. Said

Abd El-Galil E. Amr

Hassan A. El- Sayed

Mohamed A. Al- Omar

Mohamed M. Abdalla

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Research Article

Synthesized of Some Heterocyclic Systems and their Nucleoside of Potent Anti-inflammatory Activities

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