Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2015 | Volume: 11 | Issue: 5 | Page No.: 502-507
DOI: 10.3923/ijp.2015.502.507
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Synthesized of Some Heterocyclic Systems and their Nucleoside of Potent Anti-inflammatory Activities

Said A. Said, Abd El-Galil E. Amr, Hassan A. El- Sayed, Mohamed A. Al- Omar and Mohamed M. Abdalla

Abstract:
Some of synthesized heterocyclic pyrimidine, pyrimidine, furopyridine derivatives and their nucleoside candidates (2-14) were previously prepared and were founded to have some aspects of structural similarity with many anti-inflammatory agents. Therefore, these agents were screened for this property. The evaluation of the anti-inflammatory activities was based on evaluation of the abilities of these compounds in protection against carrageenan-induced edema. The anti-inflammatory activities of the tested compounds further confirmed based on evaluation of the abilities of these compounds to inhibit plasma PGE2. These compounds showed potent anti-inflammatory activity with low toxicity (LD50) comparable to Valdicoxib® as reference anti-inflammatory drugs.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Said A. Said, Abd El-Galil E. Amr, Hassan A. El- Sayed, Mohamed A. Al- Omar and Mohamed M. Abdalla, 2015. Synthesized of Some Heterocyclic Systems and their Nucleoside of Potent Anti-inflammatory Activities. International Journal of Pharmacology, 11: 502-507.

DOI: 10.3923/ijp.2015.502.507

URL: https://scialert.net/abstract/?doi=ijp.2015.502.507

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom