Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2015 | Volume: 11 | Issue: 5 | Page No.: 423-431
DOI: 10.3923/ijp.2015.423.431
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Analgesic and Anti-Inflammatory Activities of Some Newly Synthesized 3,5-Bis-[(peptidohydrazinyl) Pyridine Schiff Bases
Suzan Khayyat, Abd El-Galil E. Amr, Osama I. Abd El- Salam, Mohamed A. Al-Omar and Mohamed M. Abdalla

Abstract:
A series of bis-schiff base candidates 5a-l, 6a-c and 7a-c were synthesized by using N2, N2`-(pyridine-3,5-dicarbonyl)-di-L-lucylhydrazide (4) as starting material which was synthesized from 3,5-pyridinedicarboxylic acid (1) and screening for their analgesic and anti-inflammatory. Bis-ester 3 was prepared from 3,5-pyridinedi-carboxylic acid 1 and L-lucine methyl ester, which was hydrazonolysis with hydrazine hydrate afforded compounds 4. Treatment of acid hydrazide 4 with aromatic aldehydes afforded the corresponding bis-dipeptide Schiff bases 5a-l, respectively. Compounds 6a-c and 7a-c were synthesized by reacting of hydrazide 4 with cycloalkanone and acetyl pyridine derivatives. Some of the newly synthesized compounds exhibited better analgesic and anti-inflammatory activities than the reference controls. The structures of newly synthesized compounds were confirmed by IR, NMR, MS spectral data and elemental analysis. The detailed synthesis, spectroscopic data, pharmacological activities of the synthesized compounds was reported.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Suzan Khayyat, Abd El-Galil E. Amr, Osama I. Abd El- Salam, Mohamed A. Al-Omar and Mohamed M. Abdalla, 2015. Analgesic and Anti-Inflammatory Activities of Some Newly Synthesized 3,5-Bis-[(peptidohydrazinyl) Pyridine Schiff Bases. International Journal of Pharmacology, 11: 423-431.

DOI: 10.3923/ijp.2015.423.431

URL: https://scialert.net/abstract/?doi=ijp.2015.423.431

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom