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International Journal of Pharmacology
  Year: 2015 | Volume: 11 | Issue: 4 | Page No.: 351-358
DOI: 10.3923/ijp.2015.351.358
Pharmacokinetic Properties of Ondansetron in Combination with Ijintang-gamibang, Polyherbal Complex in Rats
Dae-Jun Kim, Hyun-Mo Ryu, Sang-in Park, Soo-Jin Park, Chang-Hyun Song and Sae-Kwang Ku

Abstract:
Ondansetron is used mainly as an antiemetic in emetogenic cancer chemotherapy and radiotherapy and post-operative nausea and vomiting (NV). However, recent study recommend reducing ondansetron dose because of possible life-threaten cardiotoxicity problems. Ijintang-gamibang (IJTGMB) is a polyherb complex, a famous traditional digestive drug in Korean medicine, which has shown the protective and functional benefits in gastrointestinal impairments. Therefore, the influences of IJTGMB on ondansetron pharmacokinetics were examined for the combination therapy. One batch of rats received single dosing of ondansetron with IJTGMB (combination) or ondansetron with distilled water (control). The IJTGMB or distilled water was co-administered orally within 5 min after ondansetron. Another batch of rats received repeated dosing of the combination for 8 days after pretreatments with IJTGMB for 6 days or the control for 8 days after pretreatments with distilled water for 6 days. The plasma samples were analyzed by various pharmacokinetic parameters including T max, C max, AUC, t 1/2 and MRT inf. In the single dosing, plasma concentration of ondansetron was not different between the combination and control and the pharmacokinetic parameters were not different between the both treatments. In the initial treatment of the repeated dosing after the pretreatments, the kinetics of ondansetron concentration and the pharmacokinetic parameters showed no differences between the both treatments. It suggests little influences of IJTGMB on ondansetron pharmacokinetics in single dosing with or without pretreatments with IJTGMB. However, after repeated dosing for 8 days, ondansetron in plasma was detected lower and longer in the combination than control. In addition, among the parameters assessed here, AUC of ondansetron was significantly reduced in combination compared to control, meaning reduced bioavailability of ondansetron by repeated co-administration with IJTGMB for 8 days. These may provide useful information for proper dosing regimen of the novel combination therapy.
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How to cite this article:

Dae-Jun Kim, Hyun-Mo Ryu, Sang-in Park, Soo-Jin Park, Chang-Hyun Song and Sae-Kwang Ku, 2015. Pharmacokinetic Properties of Ondansetron in Combination with Ijintang-gamibang, Polyherbal Complex in Rats. International Journal of Pharmacology, 11: 351-358.

DOI: 10.3923/ijp.2015.351.358

URL: https://scialert.net/abstract/?doi=ijp.2015.351.358

 
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