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International Journal of Pharmacology
  Year: 2015 | Volume: 11 | Issue: 4 | Page No.: 335-342
DOI: 10.3923/ijp.2015.335.342
Bicuculline Ameliorated Chronic, but not Acute, Stress-Induced Feeding Suppression
Joo Young Lee, Jin Young Kim, Vitaly Ryu, Bom-Taeck Kim, JaeHyung Koo, Jong-Ho Lee and Jeong Won Jahng

Abstract:
This study was conducted to examine if γ-amino Butyric Acid (GABA)-ergic neurotransmission is implicated in the regulation of stress-induced feeding. Rats received GABAA receptor antagonist bicuculline before each stress session during 10 days of daily restraint stress. The hypothalamic mRNA expressions of corticotropin-releasing hormone and neuropeptide Y were analyzed by in situ hybridization and the plasma corticosterone with radioimmunoassay. Bicuculline ameliorated the decrease in food intake by repeated restraints but not by a single restraint. Corticosterone increase responding to acute stress but not to repeated restraints was attenuated by bicuculline. Stress-induced expression of corticotropin-releasing hormone was blunted by bicuculline pre-treatment. Restraint stress did not affect neuropeptide Y expression, regardless of bicuculline pre-treatment. It is concluded that GABAA receptors may mediate chronic but not acute, stress-induced suppression in food intake, possibly in relation with anorectic action of the hypothalamic corticotropin-releasing hormone and the hypothalamic neuropeptide Y may not be implicated in its regulatory mechanism.
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How to cite this article:

Joo Young Lee, Jin Young Kim, Vitaly Ryu, Bom-Taeck Kim, JaeHyung Koo, Jong-Ho Lee and Jeong Won Jahng, 2015. Bicuculline Ameliorated Chronic, but not Acute, Stress-Induced Feeding Suppression. International Journal of Pharmacology, 11: 335-342.

DOI: 10.3923/ijp.2015.335.342

URL: https://scialert.net/abstract/?doi=ijp.2015.335.342

 
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