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International Journal of Pharmacology
  Year: 2015 | Volume: 11 | Issue: 4 | Page No.: 327-334
DOI: 10.3923/ijp.2015.327.334
Antihypertensive and Vasorelaxant Effect of Alstonia scholaris Stem Bark Extracts and Fractions
Bello Idris, Mohammad Zaini Asmawi, Usman Salisu Nasiba, Roziahanim Mahmud and Kabiru Abubakar

Abstract:
Alstonia scholaris (AS) have been widely studied for its several pharmacological benefits and has been used in folklore medicine to lower blood pressure. The present study was carried out to verify the antihypertensive and vasorelaxant effect of A. scholaris. Male Spontaneously Hypertensive Rats (SHRs) were divided into four groups; Two control groups (positive and negative control) and two test groups of six rats (n = 6). Test groups were given daily oral administration of the methanolic (ASME) and water (ASWE) extracts (1000 mg kg-1 day-1) of A. scholaris while positive and negative control groups received Verapamil (15 mg kg-1) and water respectively for 2 weeks. Vasorelaxant effect of AS extracts and its fractions were also evaluated on Endothelium-intact and denuded rat aortic ring preparations pre-contracted with either Phenylephrine (PE, 1 μM) or KCl (80 mM). Daily oral administration of the methanol extract (1000 mg kg-1 for 2 weeks) exhibited a significant decrease in blood pressure (p<0.05) in SHR rats compared to aqueous extract. All extracts and fractions (0.125-4 mg mL-1) gave a dose-dependent vasorelaxation on endothelium-intact aortic rings pre-contracted with phenylephrine (1 μM) or KCl (80 mM). Alstonia scholaris (AS) showed blood pressure lowering activity in in vivo rat model and vasorelaxation effect on pre-contracted aortic rings possibly via endothelium independent mechanisms that need further evaluation. The result also indicates its potent negative chromotropic and ionotropic effect which also augment its antihypertensive property.
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How to cite this article:

Bello Idris, Mohammad Zaini Asmawi, Usman Salisu Nasiba, Roziahanim Mahmud and Kabiru Abubakar, 2015. Antihypertensive and Vasorelaxant Effect of Alstonia scholaris Stem Bark Extracts and Fractions. International Journal of Pharmacology, 11: 327-334.

DOI: 10.3923/ijp.2015.327.334

URL: https://scialert.net/abstract/?doi=ijp.2015.327.334

 
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