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Protective Effects of Water Extract of Propolis on Dopaminergic Neurons, Brain
Derived Neurotrophic Factor and Stress Oxidative Factors in the Rat Model of
Parkinson’s Disease |
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Manouchehr Safari,
Hamid Reza Sameni,
Leila Badban,
Ahmad Raze Bandegi,
Abbas Ali Vafaei,
Ali Rashidy Pour and Laya Ghahari |
Abstract:
Propolis is a resinous natural live product derived from plant exudates collected
by honey bees. It has been extensively used in folk medicine. In the present
study, the neuroprotective effects of propolis was investigated in the rat model
of Parkinson’s disease. The PD rats which was induced by 6-OHDA were compared
with control (C) and treatment groups with different dose of Propolis. After
4 weeks of follow-up, behavioral activity, tyrosine hydroxylase positive neurons
in substantia nigra pars compacta, brain derived neurotrophic factor in serum
and brain and stress oxidative factors such as superoxide dismutase, glutathione
peroxidase activity, malondialdehyde and ferric reducing ability of plasma in
the substantia nigra were analyzed. It was confirmed that 6-OHDA led to behavioral
deficits, reduction in superoxide dismutase (6.02±0.1), glutathione peroxidase
activity (0.12±0.01), ferric reducing ability of plasma (0.72±0.09) and the
elevation of malondialdehyde levels (6.70±0.2) in the substantia nigra. When
Propolis administered prior to 6-OHDA, improved motor coordination, increased
superoxide dismutase (6.66±0.1), glutathione peroxidase (0.20±0.01) and ferric
reducing ability of plasma (0.76±0.01) activity and reduced the content of malondialdehyde
(6.2±0.1) compared with rat treated with 6-OHDA alone. Immunohistochemical studies
showed that medication of propolis could prevent the loss of tyrosine hydroxylase
positive neurons induced by 6-OHDA (107±5.77 vs 63±6.58). Decrease brain derived
neurotrophic factor and some stress oxidative factors has an important effect
in damage of tyrosine hydroxylase neurons in the brain. Propolis improves these
factors and protects tyrosine hydroxylase neurons in the brain.
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How to cite this article:
Manouchehr Safari, Hamid Reza Sameni, Leila Badban, Ahmad Raze Bandegi, Abbas Ali Vafaei, Ali Rashidy Pour and Laya Ghahari, 2015. Protective Effects of Water Extract of Propolis on Dopaminergic Neurons, Brain
Derived Neurotrophic Factor and Stress Oxidative Factors in the Rat Model of
Parkinson’s Disease. International Journal of Pharmacology, 11: 300-308.
DOI: 10.3923/ijp.2015.300.308
URL: https://scialert.net/abstract/?doi=ijp.2015.300.308
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