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International Journal of Pharmacology

Year: 2015 | Volume: 11 | Issue: 3 | Page No.: 243-247
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Authors

Yousef Altaher

Masayuki Nakanishi

Mahmoud Kandeel

Keywords

Research Article

Annotation of Camel Genome for Estimation of Drug Binding Power, Evolution and Adaption of Cytochrome P450 1a2

Yousef Altaher, Masayuki Nakanishi and Mahmoud Kandeel
While camels rapidly evoluted several genes to adapt their environment, contemporary studies recorded that camels are sensitive to toxicity with some drugs as monensin, narasin and maduramicin ionophores compounds, which are extensively used in veterinary medicine. Recently, camel genome was resolved, which will allow for discovery of secrets of camel life. To this end, it is not known whether camel cytochrome enzymes were specially developed or adapted to camel environment or it has been associated with increasing the susceptibility of camels to toxicity with drugs. The objectives of this work are annotation of camel genome and retrieval of camel for cytochrome P450 1A2 (CYP 1A2) for phylogenetic, molecular modeling studies, docking studies and determination of its drug binding power. Results indicated poor efficiency of camel CYP 1A2 in binding with drugs. Furthermore, despite the high evolution of many camel genes to adapt camel environment, CYP 1A2 was found to be phylogenetically retarded gene showing lower rate of evolution compared with subset of data from 100 different organisms. These results suggests the potential toxicity of camels with drugs undergoing oxidation by CYP 1A2.
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