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International Journal of Pharmacology
  Year: 2014 | Volume: 10 | Issue: 8 | Page No.: 406-417
DOI: 10.3923/ijp.2014.406.417
Sub-Chronic Cerebrolysin Treatment Attenuates the Long-lasting Behavioral Alterations Caused by Maternal Separation in Rats
Claudia P. Sanchez-Olguin, Sonia Guzman-Velazquez, Angel I. Melo, Gonzalo Flores, Fidel De-La-Cruz and Sergio R. Zamudio

Abstract:
Maternal separation disrupts mother-infant interactions during early life and produce long-lasting effects on physiological and behavioral processes in offspring. Maternal separation in rats can produce schizophrenia-like behaviors, such as stress hyper-reactivity, deficits in sensorimotor gating and disruption of cognitive processes and these behavioral dysfunctions can persist throughout adulthood. A neurotrophic peptide mixture, cerebrolysin, reduces behavioral and neuropathological alterations in a neurodevelopmental model of schizophrenia. This study examined the beneficial effects of sub-chronic cerebrolysin administration on long-lasting behavioral alterations caused by pre-weaning repeated maternal separation in rats. Cerebrolysin was administered daily for 4 weeks to 1 month old rats. The results showed that cerebrolysin treatment during post-pubertal age (2-3 months) reduced the hyper-reactivity to novel environment caused by maternal separation. Furthermore, this study also demonstrated that cerebrolysin administration partially reverted maternal separation-induced alterations in the acoustic startle response and its habituation process. These results suggest that cerebrolysin may exert beneficial effects in the management of some neuropsychiatric disorders.
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How to cite this article:

Claudia P. Sanchez-Olguin, Sonia Guzman-Velazquez, Angel I. Melo, Gonzalo Flores, Fidel De-La-Cruz and Sergio R. Zamudio, 2014. Sub-Chronic Cerebrolysin Treatment Attenuates the Long-lasting Behavioral Alterations Caused by Maternal Separation in Rats. International Journal of Pharmacology, 10: 406-417.

DOI: 10.3923/ijp.2014.406.417

URL: https://scialert.net/abstract/?doi=ijp.2014.406.417

 
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