Submit Manuscript

International Journal of Pharmacology

Year: 2014 | Volume: 10 | Issue: 4 | Page No.: 231-236
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 44

Authors

Liping Wan

Chun Wang

Lin Liu

Xiaoqiong Tang

Jinghua Wang

Yue Guan

Ming Jiang

Xianlin Duan

Xiaoyan Ke

Hongmei Jing

Jiong Hu

Ling Wang

Yuming Li

Li Geng

Keywords

Invasive Fungal Disease (IFD) is a major cause of death in severe neutropenic patients with hematologic malignancies. Micafungin, a new echinocandin antifungal drug, is effective in treating IFD. However, the efficacy and safety of micafungin in preventing IFD in severe neutropenic patients with hematologic malignancies have not been demonstrated. A prospective and multicenter clinical study was conducted to evaluate the efficacy and safety of micafungin as prophylaxis for IFD. Micafungin 50 mg daily was administered intravenously to 117 high-risk patients with hematologic malignancies undergoing intensive chemotherapy or Hematopoietic Stem Cell Transplantation (HSCT), for a median of 24 days. Successful prophylaxis (no proven, probable or possible IFD up to 1 week after the end of prophylactic treatment) was achieved in 88.54% patients. No patient developed proven IFD during treatment and only 2.08% had probable IFD and 9.38% possible IFD. Micafungin potentially accounted for adverse events in 6.84% of patients. No severe adverse events attributable to micafungin were seen. Micafungin 50 mg daily is a promising prophylactic antifungal therapy for neutropenic patients with hematologic malignancies.
PDF Fulltext XML References Citation

How to cite this article

Liping Wan, Chun Wang, Lin Liu, Xiaoqiong Tang, Jinghua Wang, Yue Guan, Ming Jiang, Xianlin Duan, Xiaoyan Ke, Hongmei Jing, Jiong Hu, Ling Wang, Yuming Li and Li Geng, 2014. Efficacy and Safety of Micafungin as Prophylaxis for Invasive Fungal Disease in Neutropenic Patients with Hematologic Malignancies. International Journal of Pharmacology, 10: 231-236.

DOI: 10.3923/ijp.2014.231.236

URL: https://scialert.net/abstract/?doi=ijp.2014.231.236

Leave a Comment

Your email address will not be published. Required fields are marked *