Citrullus lanatus Extract Reverses Oxidative and Haematological Dysfunction in Carbon Tetrachloride Induced Liver Damaged Rats


	International Journal of Pharmacology
	Year: 2014 \| Volume: 10 \| Issue: 4 \| Page No.: 218-224 DOI: 10.3923/ijp.2014.218.224

Citrullus lanatus Extract Reverses Oxidative and Haematological Dysfunction in Carbon Tetrachloride Induced Liver Damaged Rats

Abiodun Humphrey Adebayo, Fu Hang Song, Xue Ting Liu, Huanqin Dai, Pei Huang, Jingyu Zhang and Li Xin Zhang

Abstract: The study was carried out to evaluate the oxidative and haematologic effects of extract of Citrullus lanatus in carbon tetrachloride (CCl₄) induced liver damaged rats. Thirty male albino rats were divided into five groups of six animals per group. The normal group was administered with distilled water for seven days. CCl₄ treated group was given vehicle on the first four days and with the vehicle and hepatotoxin on the fifth, sixth and seventh day. The animals in the treatment category were respectively administered with 500, 1,000 and 1,500 mg kg^-1 b.wt. of extract for the first four days and with extract and CCl₄ on the last three days. There was significantly reduced (p<0.05) levels of catalase (CAT), superoxide dismutase (SOD), Glucose 6-Phosphate Dehydrogenase (G6PD), Packed Cell Volume (PCV) and haemoglobin (Hb) concentration in Ccl₄ treated rats but were however, normalized by the extract. Furthermore, the activities of Gluthathione s-transferase (GST) and malondialdehyde (MDA) in plasma were significantly increased (p<0.05) in CCl₄ treated group when compared with normal control rats, these were stabilized by the groups treated with the plant extract. Our findings suggest that C. lanatus exhibited reversal effects on these selected oxidative stress and haematologic markers in rats which were previously damaged by CCl₄.

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How to cite this article:

Abiodun Humphrey Adebayo, Fu Hang Song, Xue Ting Liu, Huanqin Dai, Pei Huang, Jingyu Zhang and Li Xin Zhang, 2014. Citrullus lanatus Extract Reverses Oxidative and Haematological Dysfunction in Carbon Tetrachloride Induced Liver Damaged Rats . International Journal of Pharmacology, 10: 218-224.

DOI: 10.3923/ijp.2014.218.224

URL: https://scialert.net/abstract/?doi=ijp.2014.218.224

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