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International Journal of Pharmacology

Year: 2014 | Volume: 10 | Issue: 3 | Page No.: 175-181
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Authors

Li Xiaodan

Ning Chi

Zhou Zhen

Wang Guanxi

Yang Guangwen

Guo Yunliang

Keywords

Research Article

ZJXG Decoctions Enhance the Fracture Healing by Keeping the Serum Levels of GH,CT and PTH in Rats with Femur Fracture

Li Xiaodan, Ning Chi, Zhou Zhen, Wang Guanxi, Yang Guangwen and Guo Yunliang
The aim is to investigate the effects of Zhuang Jin Xu Gu (ZJXG) decoction on the serum levels of Growth Hormone (GH), Calcitonin (CT) and Parathyroid Hormone (PTH) and the femoral fracture healing in rats. Femur fractures were generated in 72 male adult Wistar rats by cutting femur transversely at the middle point. The ZJXG decoction was administered orally as drinking water after surgery for 28 days. The healing process was analyzed by X-ray, gross anatomy and Hematoxtlin Eosin (HE) staining. The serum levels of GH, CT and PTH were assessed by enzyme linked immunosorbent assay (ELISA). X-ray, gross anatomy and HE staining indicated that the fracture line of the femoral fracture-end was clear at 7th day, fibrous callus tissue formed at 14th day, Calcium salt deposited at 21th day and osseous callus tissues formed at 28th day. During fracture (7-21 day), no difference of the callus tissue structure existed between model and treatment groups, but in treatment group it was better than that in model group at 28th day. ELISA results showed that the serum levels of GH, CT and PTH were higher than those in the control group at 7-28 days (p<0.05). There were no significant difference between model and treatment groups at 7-21 days, but in treatment group it was higher than that in model group at 28th day (p<0.05). So, ZJXG decoction could promote the fracture healing by reducing the decomposition of GH, CT and PTH and keeping their high levels in rats with femur fracture.
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