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International Journal of Pharmacology
  Year: 2014 | Volume: 10 | Issue: 2 | Page No.: 120-128
DOI: 10.3923/ijp.2014.120.128
 
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Haloperidol and Clozapine Reverse MK-801-Induced Deficits in Hypoactivity, but Not the Impairment of Spatial Memory in Sprague-Dawley Rats

Huanzhong Liu, Zhenhua Ren, Jian Zhong, Han Cai, Xuequan Chen and Jun Li

Abstract:
Blockade of the NMDA receptor by the use of MK-801 during the early postnatal period has been proposed to be an experimental model which induces behavioural changes that mimic positive, negative and cognitive symptoms of schizophrenia. We provide an overview of the effects of early life MK-801 administration on body weight, locomotor activity and spatial memory and assessed the long term behavioural profile arising from this early life manipulation. We found that intraperitoneal administration of MK-801 (0.35 mg kg-1) twice a day for 2 weeks in rat pups on postnatal days 7, showed a significant weight loss, hypoactivity and the damage of spatial memory. The long term behavioural profile showed that hypoactivity continuously reduced until 11 weeks after MK-801 administration in animal model. But for spatial memory, a short term damage was observed in model rats. After the treatment with clozapine or haloperidol, a recovery in locomotor activity was observed in the rats of model group. However, there was no effect on the spatial memory in model rat after drug treatment. The results of the present study demonstrated that clozapine and haloperidol might reverse a long lasting hypoactivity induced by repeated treatment with MK-801 in neonatal rats but no effect on a short term damage of spatial memory.
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How to cite this article:

Huanzhong Liu, Zhenhua Ren, Jian Zhong, Han Cai, Xuequan Chen and Jun Li, 2014. Haloperidol and Clozapine Reverse MK-801-Induced Deficits in Hypoactivity, but Not the Impairment of Spatial Memory in Sprague-Dawley Rats. International Journal of Pharmacology, 10: 120-128.

DOI: 10.3923/ijp.2014.120.128

URL: https://scialert.net/abstract/?doi=ijp.2014.120.128

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