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| Effect of Morinda citrifolia (Noni) Fruit Juice on Antioxidant, Hematological and Biochemical Parameters in N-Methyl-N-Nitrosourea(NMU) Induced Mammary Carcinogenesis in Sprague-Dawley Rats |
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Mani Saminathan,
Ram Bahal Rai,
Kuldeep Dhama,
Babu Lal Jangir,
Subramaniyam Suresh,
Gopikunte Jayaramaiah Ranganath,
Inbaraj Sophia,
Kuppusamy Karuppanasamy,
Singaram Barathiraja and Arumugam Gopalakrishnan |
Abstract:
N-Methyl-N-Nitrosourea (NMU) is a highly specific mammary gland carcinogen
that act directly and does not require metabolic activation. The novel medicinal
plant Morinda citrifolia, also called as Noni, has broad therapeutic
effects such as antibacterial, antiviral, antifungal, anticancer, analgesic,
anti-inflammatory, anti-oxidant and immune enhancing effects. The present study
was conducted to assess the beneficial effects of M. citrifolia fruit
juice on antioxidant, hematological and biochemical alterations caused by NMU
induced mammary carcinogenesis in Sprague-Dawley rats. The rats were divided
into five groups viz., vehicle control group-A (n = 8), M. citrifolia
control group-B (n = 8), NMU control group C (n = 15), M. citrifolia prevention
group-D (n = 15) and M. citrifolia treatment group-E (n = 15). By the
end of the 28 weeks experimental period all the animals were euthanized, blood
was collected by heart puncture. M. citrifolia treatment significantly
(p<0.05) increased the anti-oxidant enzymes such as catalase, superoxide
dismutase and significantly (p<0.05) decreased the lipid peroxidation activity
when compared to NMU control group-C. M. citrifolia exhibited a preventive
effect against anaemia, lymphocytosis and neutrophilia in group-D and group-E
when compared to group-C. Biochemical analyses showed normal levels of enzymes
of liver and kidney in M. citrifolia treated groups- B, D and E rats,
whereas NMU control group-C showed significant (p<0.05) decrease in albumin
and total protein levels. These findings indicate that M. citrifolia fruit
juice did not show any hepatotoxic or nephrotoxic effects. It was concluded
that the M. citrifolia fruit juice ameliorates the adverse effects of
NMU carcinogenesis and could be useful to treat mammary tumours in humans and
animals.
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How to cite this article:
Mani Saminathan, Ram Bahal Rai, Kuldeep Dhama, Babu Lal Jangir, Subramaniyam Suresh, Gopikunte Jayaramaiah Ranganath, Inbaraj Sophia, Kuppusamy Karuppanasamy, Singaram Barathiraja and Arumugam Gopalakrishnan, 2014. Effect of Morinda citrifolia (Noni) Fruit Juice on Antioxidant, Hematological and Biochemical Parameters in N-Methyl-N-Nitrosourea(NMU) Induced Mammary Carcinogenesis in Sprague-Dawley Rats. International Journal of Pharmacology, 10: 109-119.
DOI: 10.3923/ijp.2014.109.119
URL: https://scialert.net/abstract/?doi=ijp.2014.109.119
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