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International Journal of Pharmacology

Year: 2014 | Volume: 10 | Issue: 2 | Page No.: 109-119
DOI: 10.3923/ijp.2014.109.119

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Authors


Mani Saminathan

Country: India

Ram Bahal Rai

Country: India

Kuldeep Dhama

Country: India

Babu Lal Jangir

Country: India

Subramaniyam Suresh

Country: India

Gopikunte Jayaramaiah Ranganath

Country: India

Inbaraj Sophia

Country: India

Kuppusamy Karuppanasamy

Country: India

Singaram Barathiraja

Country: India

Arumugam Gopalakrishnan

Country: India

Keywords


  • hematology
  • antioxidant
  • N-Methyl-N-Nitrosourea induced mammary carcinogenesis
  • Morinda citrifolia fruit juice
  • biochemical parameters
  • cancer
  • amelioration
  • treatment
  • rats
Research Article

Effect of Morinda citrifolia (Noni) Fruit Juice on Antioxidant, Hematological and Biochemical Parameters in N-Methyl-N-Nitrosourea(NMU) Induced Mammary Carcinogenesis in Sprague-Dawley Rats

Mani Saminathan, Ram Bahal Rai, Kuldeep Dhama, Babu Lal Jangir, Subramaniyam Suresh, Gopikunte Jayaramaiah Ranganath, Inbaraj Sophia, Kuppusamy Karuppanasamy, Singaram Barathiraja and Arumugam Gopalakrishnan
N-Methyl-N-Nitrosourea (NMU) is a highly specific mammary gland carcinogen that act directly and does not require metabolic activation. The novel medicinal plant Morinda citrifolia, also called as Noni, has broad therapeutic effects such as antibacterial, antiviral, antifungal, anticancer, analgesic, anti-inflammatory, anti-oxidant and immune enhancing effects. The present study was conducted to assess the beneficial effects of M. citrifolia fruit juice on antioxidant, hematological and biochemical alterations caused by NMU induced mammary carcinogenesis in Sprague-Dawley rats. The rats were divided into five groups viz., vehicle control group-A (n = 8), M. citrifolia control group-B (n = 8), NMU control group C (n = 15), M. citrifolia prevention group-D (n = 15) and M. citrifolia treatment group-E (n = 15). By the end of the 28 weeks experimental period all the animals were euthanized, blood was collected by heart puncture. M. citrifolia treatment significantly (p<0.05) increased the anti-oxidant enzymes such as catalase, superoxide dismutase and significantly (p<0.05) decreased the lipid peroxidation activity when compared to NMU control group-C. M. citrifolia exhibited a preventive effect against anaemia, lymphocytosis and neutrophilia in group-D and group-E when compared to group-C. Biochemical analyses showed normal levels of enzymes of liver and kidney in M. citrifolia treated groups- B, D and E rats, whereas NMU control group-C showed significant (p<0.05) decrease in albumin and total protein levels. These findings indicate that M. citrifolia fruit juice did not show any hepatotoxic or nephrotoxic effects. It was concluded that the M. citrifolia fruit juice ameliorates the adverse effects of NMU carcinogenesis and could be useful to treat mammary tumours in humans and animals.
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How to cite this article

Mani Saminathan, Ram Bahal Rai, Kuldeep Dhama, Babu Lal Jangir, Subramaniyam Suresh, Gopikunte Jayaramaiah Ranganath, Inbaraj Sophia, Kuppusamy Karuppanasamy, Singaram Barathiraja and Arumugam Gopalakrishnan, 2014. Effect of Morinda citrifolia (Noni) Fruit Juice on Antioxidant, Hematological and Biochemical Parameters in N-Methyl-N-Nitrosourea(NMU) Induced Mammary Carcinogenesis in Sprague-Dawley Rats. International Journal of Pharmacology, 10: 109-119.

DOI: 10.3923/ijp.2014.109.119

URL: https://scialert.net/abstract/?doi=ijp.2014.109.119

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