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International Journal of Pharmacology
  Year: 2013 | Volume: 9 | Issue: 8 | Page No.: 533-537
DOI: 10.3923/ijp.2013.533.537
 
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Anti-inflammatory Properties of Quercetin-3-O-β-D-glucuronide-methyl Ester from Polygonum perfoliatum in Mice

Xiaojian Gong, Xin Zhou, Chao Zhao, Huaguo Chen and Yang Zhao

Abstract:
Polygonum perfoliatum is commonly used in folk medicine to treat inflammatory disorders in China. Present studies on the anti-inflammation effect of quercetin-3-O-β-D-glucuronide-methyl ester from Polygonum perfoliatum was evaluated in vivo models of both acute inflammations such as xylene-induced ear edema, acetic acid-induced vascular permeability. Quercetin-3-O-β-D-glucuronide-methyl ester showed a significant dose-related inhibition in xylene-induced ear swelling and acid-induced vascular permeability in mice. These results demonstrate that quercetin-3-O-β-D-glucuronide-methyl ester possesses a potent anti-inflammatory function on acute inflammation. These results also support the claims of traditional Chinese medicine practitioners about the use of Polygonum perfoliatum in the treatment of inflammatory disease.
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How to cite this article:

Xiaojian Gong, Xin Zhou, Chao Zhao, Huaguo Chen and Yang Zhao, 2013. Anti-inflammatory Properties of Quercetin-3-O-β-D-glucuronide-methyl Ester from Polygonum perfoliatum in Mice. International Journal of Pharmacology, 9: 533-537.

DOI: 10.3923/ijp.2013.533.537

URL: https://scialert.net/abstract/?doi=ijp.2013.533.537

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