Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2013 | Volume: 9 | Issue: 8 | Page No.: 524-532
DOI: 10.3923/ijp.2013.524.532
Inhibitory Effect of Sargassum patens on Inflammation and Melanogenesis
Kil-Nam Kim, Jihyeon Kim, Weon-Jong Yoon, Hye-Mi Yang, Soo Yeon Heo, Ji-Yeon Ko, Seong Woon Roh, You-Jin Jeon, Sung-Myung Kang, Soo-Jin Heo, Kalpa W. Samarakoon, Dong-Sam Kim and Daekyung Kim

Abstract:
Many seaweed species are used as traditional medicine in different parts of the world. However, data on the anti-inflammatory and anti-melanogenic effects of seaweeds are scarce. This study investigated the inhibitory activity of ethyl acetate extracts of Sargassum patens (ESP) on the production of inflammatory cytokines and melanin synthesis in cultured cell lines in vitro. ESP significantly inhibited the production of Nitric Oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-6 and tumor necrosis factor (TNF-α) on the lipopolysaccharide (LPS)-stimulated RAW264.7 cells. In addition, ESP suppressed the protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated RAW264.7 cells. ESP markedly inhibited α-melanocyte stimulating hormone (α-MSH)-induced melanin synthesis and tyrosinase activity and also decreased α-MSH-induced expression of microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1 and TRP-2 in B16 F10 cells. Furthermore, High Performance Liquid Chromatography (HPLC) fingerprinting of ESP revealed that fucoxanthin was the major component of these extracts.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    In vitro Cytotoxic Activity of Sargassum thunbergii and Dictyopteris divaricata (Jeju Seaweeds) on the HL-60 Tumour Cell Line
  •    Effect of Korean Red Sea Cucumber (Stichopus japonicus) on Melanogenic Protein Expression in Murine B16 Melanoma
How to cite this article:

Kil-Nam Kim, Jihyeon Kim, Weon-Jong Yoon, Hye-Mi Yang, Soo Yeon Heo, Ji-Yeon Ko, Seong Woon Roh, You-Jin Jeon, Sung-Myung Kang, Soo-Jin Heo, Kalpa W. Samarakoon, Dong-Sam Kim and Daekyung Kim, 2013. Inhibitory Effect of Sargassum patens on Inflammation and Melanogenesis. International Journal of Pharmacology, 9: 524-532.

DOI: 10.3923/ijp.2013.524.532

URL: https://scialert.net/abstract/?doi=ijp.2013.524.532

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom