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International Journal of Pharmacology

Year: 2013 | Volume: 9 | Issue: 7 | Page No.: 390-404
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Authors

Mohammed S. El-Hersh

Husain A. El-Fadaly

Wesam I.A. Saber

Amany M. El-Deeb

Keywords

Hepatitis B and C viruses are major etiologic agents of acute and chronic viral hepatitis especially in many developing countries by which the food toxins sustained viral hepatocarcinoma. Developed abnormal liver lesions were found in mice during infection with hepatitis B virusxprotein and exposure to diethylnitrosamine. In addition, chronic HBV infection and exposure to dietary aflatoxin are important risk factor in the development of hepatocellular carcinoma. Whereas lymphocyte infiltration to periportal areas and damaged bile duct are usually recognized in liver with chronic hepatitis C virus. Moreover, biogenic amines, i.e., histamine, cadaverine or putrescine were found to cause hepatocytes inflammation and lesions during intraperitoneally injection of mice. Moreover, hepatocytes apoptosis was a human pathological feature as a result of alcoholic consumption.
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