Submit Manuscript

International Journal of Pharmacology

Year: 2013 | Volume: 9 | Issue: 4 | Page No.: 271-276
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 46

Authors

Ibrahim A. Alhaider

Keywords

Research Article

Effects of Edaravone on Scopolamine Induced-dementia in Experimental Rats

Ibrahim A. Alhaider
It has been shown that edaravone and scopolamine have contrasting effects on memory; therefore, this research paper was undertaken to evaluate the impact of edaravone treatment on learning and long-term memory shortage coupled with scopolamine induced dementia. The results showed that chronic edaravone treatment averted the deficit of long-term memory as measured by transfer latency using spatial cues in the elevated plus maze task. Moreover, edaravone protected against the weakening of antioxidant defense activity in the areas of hippocampi and cerebral cortices of scopolamine treated rats. Furthermore, the thiobarbituric acid reactive substances test revealed that edaravone prevented the detrimental effects of scopolamine on lipid peroxidation (p<0.01). The results suggest that edaravone treatment protected against the scopolamine generated memory deficit probably by preserving the levels of reduced glutathione and TBARS. Hence, it is found to possess neuroprotective effects in scopolamine induced memory impairment model.
PDF Fulltext XML References Citation

Leave a Comment

Your email address will not be published. Required fields are marked *