Study on the Pharmacokinetics of Tacrolimus in Depression Model Rats

Research Article

Study on the Pharmacokinetics of Tacrolimus in Depression Model Rats

Jingjing Duan, Yingtong Zeng, Ting Zhou, Ye Zhang and Feng Xu

Drug metabolism is affected by many social-psychological factors including mood disorder. Organ transplantation recipients usually suffer from depression. The study aims to explore whether depression disorder alters immunosuppresant Tacrolimus (TAC) pharmacokinetic process in depression model rats. Eighteen female Sprague-Dawley (SD) rats were randomized into model group and control group. Depression model rats were built with Chronic Unpredicted Mild Stresses (CUMS) for 8 weeks. After 8 weeks model establishment, all rats in both groups were given TAC (1.5 mg kg^-1) i.g. Blood samples were collected at various time points. TAC concentration was assayed by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). TAC pharmacokinetic parameters were processed with DAS software. Compared to those in control group, there was significant decrease in C_max and AUC in depression model group (p<0.05), from 0.87±0.06 to 0.79±0.05 μg mL^-1 (C_max) and from 2.35±0.23 to 2.14±0.08 μg mL^-1•h (AUC), respectively. The results indicated that depression disorder alter TAC pharmacokinetic process which might be induced by enhancing the drug metabolism.

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Jingjing Duan, Yingtong Zeng, Ting Zhou, Ye Zhang and Feng Xu, 2013. Study on the Pharmacokinetics of Tacrolimus in Depression Model Rats. International Journal of Pharmacology, 9: 265-270.

DOI: 10.3923/ijp.2013.265.270

URL: https://scialert.net/abstract/?doi=ijp.2013.265.270

International Journal of Pharmacology

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Authors

Jingjing Duan

Yingtong Zeng

Ting Zhou

Ye Zhang

Feng Xu

Keywords

Research Article

Study on the Pharmacokinetics of Tacrolimus in Depression Model Rats

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