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International Journal of Pharmacology

Year: 2013 | Volume: 9 | Issue: 2 | Page No.: 164-169
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Authors

Bin Ren

Binghua Wei

Ruiming Li

Liang Huang

Xiaodan Hong

Xiaohua Fu

Xiao Chen

Keywords

The Danmo Capsule (DMC) is a widely used patent Chinese botanic drug, prepared with the extract of Radix salviae miltiorrhizae and Ecliptae prostratae. Drug-drug interaction of DMC and prednisone was investigated in rats via in vivo pharmacokinetic studies. After pretreatment with DMC at daily dosages of 0.432 g kg-1 for 14 consecutive days, there were significant decrease in the peak plasma concentration (Cmax) of prednisone (from 174.6±32.9 ng mL-1 to 68.2±35.2 ng mL-1, p<0.01) and in the area under the plasma concentration-time curve (AUC0-2.5h) of prednisone (from 225.9±55.8 h.ng mL-1 to 128.8±37.5 h.ng mL-1, p<0.05), respectively. In contrast to prednisone, the Cmax of prednisolone was significantly increased from 155.9±40.4 ng mL-1 to 333.20±95.8 ng mL-1 (p<0.05) and the AUC0-8h of prednisolone was significantly increased from 467.5±35.3 h.ng mL-1 to 757.3±105.4 h.ng mL-1 (p<0.01), respectively. However, no statistically significant differences for the elimination half-life (t1/2) and Mean Residence Time (MRT) of prednisone and prednisolone were detected. In conclusion, the increased Cmax and AUC of prednisolone showed co-administration with DMC significantly increased exposure of prednisolone.
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