• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Pharmacology
  2. Vol 9 (2), 2013
  3. 164-169
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Pharmacology

Year: 2013 | Volume: 9 | Issue: 2 | Page No.: 164-169
DOI: 10.3923/ijp.2013.164.169

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 71

Authors


Bin Ren

Country: China

Binghua Wei

Country: China

Ruiming Li

Country: China

Liang Huang

Country: China

Xiaodan Hong

Country: China

Xiaohua Fu

Country: China

Xiao Chen

Country: China

Keywords


  • Danmo capsules
  • interaction
  • pharmacokinetics
  • prednisolone
  • prednisone
Research Article

Study on the Pharmacokinetics Drug-drug Interaction of Danmo Capsules with Prednisone in Rats

Bin Ren, Binghua Wei, Ruiming Li, Liang Huang, Xiaodan Hong, Xiaohua Fu and Xiao Chen
The Danmo Capsule (DMC) is a widely used patent Chinese botanic drug, prepared with the extract of Radix salviae miltiorrhizae and Ecliptae prostratae. Drug-drug interaction of DMC and prednisone was investigated in rats via in vivo pharmacokinetic studies. After pretreatment with DMC at daily dosages of 0.432 g kg-1 for 14 consecutive days, there were significant decrease in the peak plasma concentration (Cmax) of prednisone (from 174.6±32.9 ng mL-1 to 68.2±35.2 ng mL-1, p<0.01) and in the area under the plasma concentration-time curve (AUC0-2.5h) of prednisone (from 225.9±55.8 h.ng mL-1 to 128.8±37.5 h.ng mL-1, p<0.05), respectively. In contrast to prednisone, the Cmax of prednisolone was significantly increased from 155.9±40.4 ng mL-1 to 333.20±95.8 ng mL-1 (p<0.05) and the AUC0-8h of prednisolone was significantly increased from 467.5±35.3 h.ng mL-1 to 757.3±105.4 h.ng mL-1 (p<0.01), respectively. However, no statistically significant differences for the elimination half-life (t1/2) and Mean Residence Time (MRT) of prednisone and prednisolone were detected. In conclusion, the increased Cmax and AUC of prednisolone showed co-administration with DMC significantly increased exposure of prednisolone.
PDF Fulltext XML References Citation

How to cite this article

Bin Ren, Binghua Wei, Ruiming Li, Liang Huang, Xiaodan Hong, Xiaohua Fu and Xiao Chen, 2013. Study on the Pharmacokinetics Drug-drug Interaction of Danmo Capsules with Prednisone in Rats. International Journal of Pharmacology, 9: 164-169.

DOI: 10.3923/ijp.2013.164.169

URL: https://scialert.net/abstract/?doi=ijp.2013.164.169

Related Articles

Tissue Distribution of Prednisone/Prednisolone is Affected by TCM Danmo Capsule in Rats

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved