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International Journal of Pharmacology

Year: 2012 | Volume: 8 | Issue: 1 | Page No.: 39-45
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Authors

Fulya Benzer

Fatih Mehmet Kandemir

Songul Ceribasi

Mustafa Ozkaraca

Nuran Cikcikoglu Yildirim

Sema Temizer Ozan

Keywords

Cisplatin (CP) is one of the most effective cancer chemotherapeutic agent used against various solid tumors. This study was designed to investigate the antioxidant effects of Grape Seed Extract (GSE) on CP induced oxidative damage in rabbit kidney. The material of study was consist of 18 male New Zealand rabbit. Animals were divided into 3 groups. The first group was administered a single intraperitoneal (i.p.) dose of 0.9% saline. The second group of rabbits was treated with CP (a single i.p. dose of 5 mg kg-1 body weight); The third group of rabbits was treated with GSE by gavage at the dose of 250 mg kg-1 body weight for 6 consecutive days before and 6 consecutive days after a single i.p. CP injection. As a result of CP administration, kidney function tests; urea, BUN (Blood Urea Nitrogen) and creatinine levels were increased (p<0.001). It was observed that CP increase malondialdehide (MDA) levels, the most important indicator of oxidative damage and decreased the activity of catalase (CAT). Administration of CP did not caused statically a change in glutathione (GSH) levels and glutathione peroxidase (GSH-PX) activity (p>0.05). GSE treatment has high levels of MDA to compared to normal levels (p<0.001) but not an increase in CAT (p<0.05). In CP treatment group, severe acute tubular necrosis was seen. It was determined that in CP+GSE group mild degenerative changes were received instead of acute tubular necrosis. GSE has been found to be partially protective effect against CP induced biochemical and histopathological changes in rabbit kidney.
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How to cite this article

Fulya Benzer, Fatih Mehmet Kandemir, Songul Ceribasi, Mustafa Ozkaraca, Nuran Cikcikoglu Yildirim and Sema Temizer Ozan, 2012. Chemotherapeutic Agent-induced Nephrotoxicity in Rabbits: Protective Role of Grape Seed Extract. International Journal of Pharmacology, 8: 39-45.

DOI: 10.3923/ijp.2012.39.45

URL: https://scialert.net/abstract/?doi=ijp.2012.39.45

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