
	International Journal of Pharmacology
	Year: 2012 \| Volume: 8 \| Issue: 5 \| Page No.: 283-305 DOI: 10.3923/ijp.2012.283.305

An Exhaustive Review on Recent Advancement in Pharmaceutical Bioadhesive Used for Systemic Drug Delivery Through Oral Mucosa for Achieving Maximum Pharmacological Response and Effect

Ajay Behra, Tapan Kumar Giri, Dulal Krishna Tripathi, Ajazuddin and Amit Alexander

Abstract: As compared to both injectable and oral delivery, the buccal delivery is preferred to and advantageous for enhancement of bioavailability of drug. The mucosal surfaces are usually rich in blood supply and provide the means for rapid drug transport to the systemic circulation avoiding drug degradation in harsh gastric environment and first-pass hepatic metabolism. Besides, it can prolong absorption and residence time due to prolonged contact with absorption surface and with the site of application allowing once or twice daily dosing. A rapid onset of action with comfort and convenience in delivery of certain drugs has been observed. Many drugs have been tried with buccal route, a few are also available commercially. Clinical need should be significant and must be high enough to counterbalance the high cost associated with development of a buccal product. Buccal drug delivery assures four times the absorption rate from the skin. The review aims the development in the buccal adhesive drug delivery systems to provide basic principles to the young researchers which will be helpful in overcoming the difficulties associated with the formulation design.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Formulation and In vitro/In vivo Evaluation of Buccoadhesive Discs for Controlled Release of Calcium Channel Antagonist

•	The Palliative Effects of Lidocaine with Adrenaline on Recurrent Aphthous Stomatitis (RAS)

•	Posterior Pillar Flap Palatoplasty: A New Surgical Technique for Treatment of Snoring: Initial Experience

•	Studies of in vitro Evaluation and Formulation of Aceclofenac Loaded PLGA Microspheres

•	Bacteria Recovered from Whole-Carcass Rinsates of Broiler Carcasses Washed in a Spray Cabinet with Lauric Acid-Potassium Hydroxide

•	Protein Precipitation Method for Salivary Proteins and Rehydration Buffer for Two-Dimensional Electrophoresis

How to cite this article:

Ajay Behra, Tapan Kumar Giri, Dulal Krishna Tripathi, Ajazuddin and Amit Alexander, 2012. An Exhaustive Review on Recent Advancement in Pharmaceutical Bioadhesive Used for Systemic Drug Delivery Through Oral Mucosa for Achieving Maximum Pharmacological Response and Effect. International Journal of Pharmacology, 8: 283-305.

DOI: 10.3923/ijp.2012.283.305

URL: https://scialert.net/abstract/?doi=ijp.2012.283.305

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Chemical Abstract Services
		EMBASE
		Google Scholar
		ISI Web of Knowledge
		Science Citation Index (EXP)
		SCIMAGO
		Thomson ISI

Science Alert