Isolation and Hypoglycemic Activity of a Novel Pongamiaflavonylflavonol from Pongamia pinnata Pods


	International Journal of Pharmacology
	Year: 2012 \| Volume: 8 \| Issue: 4 \| Page No.: 265-270 DOI: 10.3923/ijp.2012.265.270

Isolation and Hypoglycemic Activity of a Novel Pongamiaflavonylflavonol from Pongamia pinnata Pods

A. Semalty, M. Semalty, P. Kumar, S.R. Mir, M. Ali and S. Amin

Abstract: Pongamia pinnata (family Papilionaceae) has been used for bronchitis, whooping cough, rheumatic joints and quench dipsia in diabetes. This study deals with the isolation of a new hypoglycemic phytoconstituent from P. pinnata pods. The hypoglycemic activity of the isolated phytoconstituent was evaluated in comparison of the methanolic extract of the pods.. Methanolic extract of P. pinnata pods was fractionated by column chromatography and the isolated compounds were identified by spectral analysis. A new compound named Pongamiaflavonylflavonol was isolated from chloroform: methanol (97:3) eluant. This new isolated compound was studied for hypoglycemic activity in streptozotocin induced diabetic rats. Methanolic extract of P. pinnata pods and pongamiaflavonylflavonol showed significant hypoglycemic activity in streptozotocin-induced hyperglycemic rats after oral administration. At the end of 6 h the new compound showed 12.15% reduction in blood glucose level in comparison of extract (11.36%) against the standard (16.93%). It can be concluded that the novel Pongamiaflavonylflavonol isolated from P. pinnata pods may be useful as oral hypoglycemic therapeutic agent. This may serve as a lead compound for development of more potent drugs for clinical use in diabetes.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Isolation and Characterization of Novel Flavonoid from Methanolic Extract of Pongamia pinnata Pods

•	Antihyperglycaemic Activity of Cycloart-23-ene-3β, 25-diol Isolated from Stem Bark of Pongamia pinnata in Alloxan Induced Diabetic Mice

•	Effect of Plant Extracts on Okra mosaic virus Incidence and Yield Related Parameters of Okra

•	Pharmacology and Phytochemistry of Pakistani Herbs and Herbal Drugs Used for Treatment of Diabetes

•	Hypoglycemic and Hypolipidemic Activity of Pongamia pinnata (Linn.) Pierre in Streptozotocin-induced Diabetic Rats

How to cite this article:

A. Semalty, M. Semalty, P. Kumar, S.R. Mir, M. Ali and S. Amin, 2012. Isolation and Hypoglycemic Activity of a Novel Pongamiaflavonylflavonol from Pongamia pinnata Pods. International Journal of Pharmacology, 8: 265-270.

DOI: 10.3923/ijp.2012.265.270

URL: https://scialert.net/abstract/?doi=ijp.2012.265.270

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Chemical Abstract Services
		EMBASE
		Google Scholar
		ISI Web of Knowledge
		Science Citation Index (EXP)
		SCIMAGO
		Thomson ISI

Follow @scialert

Science Alert