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International Journal of Pharmacology

Year: 2012 | Volume: 8 | Issue: 4 | Page No.: 224-233
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Authors

Badrul Alam

Sarowar Hossain

Razibul Habib

Julia Rea

Anwarul Islam

Keywords

Methanolic extract of Lannea coromandelica Linn. bark (MLCB) was subjected to evaluate its antioxidant and analgesic properties. The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate as well as tail immersion method and acetic acid-induced writhing test with formalin induced pain in mice, respectively. To evaluate antioxidant potential of MLCB, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical as well as total Reactive Oxygen Species (ROS) and assessment of reducing power were used. The extract, at the dose of 200 and 400 mg kg-1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods whereas significantly (p<0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner. In DPPH and total ROS scavenging method, MLCB showed good antioxidant potentiality with the IC50 value of 12.32±0.16 and 34.72±0.48 μg mL-1, respectively with a good reducing power. In conclusion this study demonstrated the strong antioxidant and antinociceptive activities of methanolic extract of the bark of L. coromandelica. Altogether, these results suggest that the MLCB could be used as a potential antinociceptive agent along with its antioxidant potentiality.
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