• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Pharmacology
  2. Vol 8 (3), 2012
  3. 169-176
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Pharmacology

Year: 2012 | Volume: 8 | Issue: 3 | Page No.: 169-176
DOI: 10.3923/ijp.2012.169.176

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 475

Search


Authors


O.B. Idonije

Country: Nigeria

O.O. Festus

Country: Nigeria

U. Akpamu

Country: Nigeria

O. Okhiai

Country: Nigeria

O.I. Iribhogbe

Country: Nigeria

G.B.S. Iyalomhe

Country: Nigeria

Keywords


  • lipid profile
  • dyslipidaemia
  • risperidone
  • clozapine
  • Atypical antipsychotics
  • schizophrenia
Research Article

A Comparative Study of the Effects of Clozapine and Risperidone Monotherapy on Lipid Profile in Nigerian Patients with Schizophrenia

O.B. Idonije, O.O. Festus, U. Akpamu, O. Okhiai, O.I. Iribhogbe and G.B.S. Iyalomhe
Although antipsychotic drugs are known to have an array of adverse effects, they also exhibit significant differences in causing these effects. The atherogenic effects of clozapine and risperidone have not been fully investigated among schizophrenics in Nigeria hence this research work. This study therefore investigated the extent to which monotherapy with clozapine and risperidone (atypical antipsychotic drugs) influence lipid profile in patients with schizophrenia. The study population comprised 29 Schizophrenic patients from Psychiatric Hospital, Uselu, Benin city, Nigeria. They were placed on typical antipsychotics for six weeks: 10 patients were on risperidone (1-4 mg day-1 in divided doses) and 19 patients were on clozapine (25-300 mg day-1 in divided doses). The control group comprised 30 apparently healthy volunteers. Blood samples were collected from all subjects on the first day before the commencement of treatment with antipsychotic drug and 24 h after the last administration of antipsychotics at the end of week 6 for analyses of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL) and very low density Lipoprotein cholesterol (VLDL) using standard methods. Comparing with the control, the basal serum TC, TG, LDL and VLDL of the clozapine treated group were not significantly different except for HDL which was significantly reduced and the atherogenic indices (TC/HDL and LDL/HDL) which were significantly increased. However the risperidone treatment group showed significantly higher TC, TG, LDL and VLDL levels while HDL was significantly reduced. At the end of week 6, there was significant increase in serum TC, TG, HDL and VLDL and a significant decrease in HDL in both treatment groups compared to the control except VLDL that was not significantly different in the clozapine group. Comparing the two treatment groups, risperidone caused a more significant increase on lipid profile and atherogenic indeces than clozapine. This effect was about two times or greater with risperidone than clozapine. Conclusively, additional prospective clinical trials are required to support a specific therapeutic approach for managing dyslipidaemia that are present in clozapine and risperidone treated schizophrenic patients in an attempt to avoid its consequent adverse effects.
PDF Fulltext XML References Citation

How to cite this article

O.B. Idonije, O.O. Festus, U. Akpamu, O. Okhiai, O.I. Iribhogbe and G.B.S. Iyalomhe, 2012. A Comparative Study of the Effects of Clozapine and Risperidone Monotherapy on Lipid Profile in Nigerian Patients with Schizophrenia. International Journal of Pharmacology, 8: 169-176.

DOI: 10.3923/ijp.2012.169.176

URL: https://scialert.net/abstract/?doi=ijp.2012.169.176

Related Articles

Risperidone and Corrected QT-interval Prolongation in Surface Electrocardiogram
Comparative Study of Clozapine, Electroshock and the Combination of ECT with Clozapine in Treatment-Resistant Schizophrenic Patients

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved