Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2012 | Volume: 8 | Issue: 2 | Page No.: 108-114
DOI: 10.3923/ijp.2012.108.114
Immunomodulatory Effect of Withania somnifera, Asparagus racemosus and Picrorhiza kurroa Roots
Nasir Ali Siddiqui, Shobhna Singh, M. Mairaj Siddiquei and Tajdar Husain Khan

Abstract:
Withania somnifera (commonly known as “Ashwagandha”), Asparagus racemosus (Shatavari) and Picrorhiza kurroa (Kutki) are conventional herbal drugs used in Indian traditional system of medicine. They have been claimed to possess aphrodisiac, sedative, rejuvenative and life prolonging properties. In the present study, immunomodulatory properties were studied using the three models; viz., delayed type hypersensitivity reaction, neutrophil count and humoral antibody response in mice. The dried roots of W. somnifera, A. racemosus and P. kurroa were powdered and the ethanolic extract was obtained and standardized by High Performances Thin Layer Chromatography (HPTLC) method. The dried extract was administered orally as 0.1% suspension of carboxymethylcellulose at a dose of 100 mg kg-1 of body weight. After 14 days of oral administration immunomodulatory activity was done in male Swiss albino mice with and without an immunosuppressive agent Cyclophosphamide. The ethanolic extract of these herbs exhibited significant foot pad thickness in Delayed Type Hypersensitivity (DTH) reaction when measured after 24 h of sheep RBC antigen challenge in mice. W. somnifera revealed enhanced neutrophil counts and humoral antibody response. All the three selected herbs have immunostimulatory effects in common however, the overall order of immunostimulatory activity was established as W. somnifera>A. racemosus>P. kurroa.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Influence of Edaphic Factors on Distribution of Mycorrhiza Associated with Medicinal Plants in Indian Central Himalayas
  •    Herbal Plants as New Immuno-stimulator in Poultry Industry: A Review
  •    Immunomodulatory and Antioxidant Activity of a Polyherbal Formulation
  •    Cerebroprotective Effect of Root Extract of Asparagus racemosus Willd. in Global Cerebral Ischemia in Rats
How to cite this article:

Nasir Ali Siddiqui, Shobhna Singh, M. Mairaj Siddiquei and Tajdar Husain Khan, 2012. Immunomodulatory Effect of Withania somnifera, Asparagus racemosus and Picrorhiza kurroa Roots. International Journal of Pharmacology, 8: 108-114.

DOI: 10.3923/ijp.2012.108.114

URL: https://scialert.net/abstract/?doi=ijp.2012.108.114

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom