Submit Manuscript

International Journal of Pharmacology

Year: 2011 | Volume: 7 | Issue: 8 | Page No.: 829-835
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 378

Authors

Hasan Soliman Yusufoglu

Saleh Ibrahim Alqasoumi

Keywords

Research Article

Anti-inflammatory and Wound Healing Activities of Herbal Gel Containing an Antioxidant Tamarix aphylla Leaf Extract

Hasan Soliman Yusufoglu and Saleh Ibrahim Alqasoumi
Tamarix aphylla, a traditionally used plant in the Middle Eastern countries, was screened for its potential antioxidant, anti-inflammatory and wound healing effect. Antioxidant activity of T. aphylla ethanolic leaf extract was measured by 1, 1, diphenyl, 2 picryl, hydrazyl and hydrogen peroxide free radicals scavenging method. Herbal gel formulations containing 15 and 25% T. aphylla extract in gel base, namely Carbapol-934, were prepared. Further herbal gel formulations were evaluated for its anti-inflammatory activity by carrageen an induced paw edema model and wound healing activity by excision wound model in Wister rats. Percentage, reduction in paw edema and wound contraction was measured in these models. The extract showed maximum scavenging activity i.e., 80.81±0.29 and 67.76±0.09 at 400 μg mL-1 by 1, 1, diphenyl, 2 picryl, hydrazyl and hydrogen peroxide free radicals scavenging method, respectively. In carrageen an induced paw edema model and excision wound model, the formulation showed optimum percentage inhibition of 53.07 and 89.6% with 25% gel formulation which was comparable to the standard Diclomax® and Betadine®, respectively. The Present study concludes that T. aphylla leaves extract, possesses antioxidant, anti-inflammatory and wound healing activities.
PDF Fulltext XML References Citation

Related Articles

Variation in Antioxidant Activity and Phenolic and Flavonoid Contents in the Flowers and Leaves of Ghaneri (Lantana camara L.) as Affected by Different Extraction Solven
Histological Evaluation of the Healing Properties of Dead Sea Black Mud on Full-thickness Excision Cutaneous Wounds in BALB/c Mice
Potential Uses of Plant Species of the Coastal Mediterranean Region, Egypt
Salvadora persica, Tamarix aphylla and Zizyphus mauritiana-Three Woody Plant Species Mentioned in Holy Quran and Ahadith and Their Ethnobotanical Uses in North Western Part (D.I. Khan) of Pakistan

Leave a Comment

Your email address will not be published. Required fields are marked *