Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 7 | Page No.: 782-789
DOI: 10.3923/ijp.2011.782.789
Antidiabetic, Antihyperlipedemic and Antioxidant Effects of Aqueous Extract of the Roots of Cynara cornigera in Alloxan-induced Experimental Diabetes Mellitus
Mohamed Ahmida

Abstract:
Diabetes mellitus is one of the most common diseases due to which world's population suffers from it. Nowadays, the medical management of diabetes is not adequate due to the serious side effects of synthetic hypoglycemic drugs. The aim of this study was to investigate the antidiabetic, antihyperlipidemic and antioxidant activities of Cynara cornigera as an herbal drug free from side effects. Hyperglycemia was induced by a single intraperitoneal injection of alloxan (150 mg kg-1). Administration of the Cynara cornigera extract (1.5 g kg-1) and glibenclamide (10 mg kg-1) orally in diabetic rats resulted in a significant reduction (p<0.05) on blood glucose level (from 330.80±10.11 mg dL-1 to 229.70±7.94 and 195.50±6.53 mg dL-1 for the extract and for glibenclamide, respectively). In addition, it significantly recovered serum insulin levels (from 18.00±1.23 μL mL-1 to 27.00±1.19 and 32.00±1.73 μL mL-1 for the extract and for glibenclamide, respectively), liver glycogen content (from 14.80±1.10 mg g-1 to 33.65±1.96 and 39.10±2.47 mg g-1 for the extract and for glibenclamide, respectively) and prevented the decrease in body weight (from -12.5 to +4.2% and +6.2% for the extract and for glibenclamide, respectively). Hyperlipidemia, marked increase in lipid peroxide levels and concomitant decrease in glutathione content and catalase activity from homogenized liver sample were observed in untreated diabetic rats. Treatment with Cynara cornigera extract significantly reversed these conditions to near normal levels. The results of the present study show that administration of aqueous extract of the root of Cynara cornigera may be a good alternative antidiabetic agent.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    In vitro α-amylase Inhibitory Effect and Antioxidant Activity of Teucrium barbeyanum (A Libyan Ayurvedic Medicinal Plant)
  •    Changes in Body Weight and Serum Biochemical Measures of German Shepherd Dogs following Alloxan Induced Diabetes Mellitus
  •    The Study of Compositions and Antimicrobial Properties of Essential Oil of Origanum vulgare and Rosmarinus officinalis on Human Pathogens
  •    Pharmacology and Phytochemistry of Pakistani Herbs and Herbal Drugs Used for Treatment of Diabetes
  •    Hypoglycemic and Hypolipidemic Effect of Cynara Scolymus among Selected Type 2 Diabetic Individuals
How to cite this article:

Mohamed Ahmida , 2011. Antidiabetic, Antihyperlipedemic and Antioxidant Effects of Aqueous Extract of the Roots of Cynara cornigera in Alloxan-induced Experimental Diabetes Mellitus. International Journal of Pharmacology, 7: 782-789.

DOI: 10.3923/ijp.2011.782.789

URL: https://scialert.net/abstract/?doi=ijp.2011.782.789

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom