Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 6 | Page No.: 732-735
DOI: 10.3923/ijp.2011.732.735
N-acetylcysteine a Novel Treatment for Acute Human Organophosphate Poisoning
S. Shadnia, S. Ashrafivand, S. Mostafalou and M. Abdollahi

Abstract:
Since oxidative stress markers are increased in Organophosphates (OPs) toxicity, the efficacy of the antioxidant N-acetyl-L-cysteine (NAC) as an adjunct therapy to atropine and pralidoxime for acute OPs toxicity was evaluated. Twenty-four adult subjects with acute OP toxicity were included in a randomized single blind controlled trial on the use of intravenous NAC. Among included subjects, twelve were randomized to receive NAC and the rest did not receive NAC. The results showed that the needing to atropine but not pralidoxime was reduced in NAC group. The duration of hospitalization was reduced in the NAC group. Addition of NAC to current treatment protocol of acute OPs poisoning is recommended.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Place of Iron Chelators Like Desferrioxamine and Deferasirox in Management of Hyperoxia-induced Lung Injury; A Systematic Review
  •    Cost and Utilization Study of Antidotes: An Iranian Experience
How to cite this article:

S. Shadnia, S. Ashrafivand, S. Mostafalou and M. Abdollahi, 2011. N-acetylcysteine a Novel Treatment for Acute Human Organophosphate Poisoning. International Journal of Pharmacology, 7: 732-735.

DOI: 10.3923/ijp.2011.732.735

URL: https://scialert.net/abstract/?doi=ijp.2011.732.735

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom