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International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 6 | Page No.: 726-731
DOI: 10.3923/ijp.2011.726.731
Effect of Iodine Supplementation on Antioxidant Status of Normal and Alloxan Monohydrate in Toxicated Rats
Gabriel A. Agbor, Ibrahim Taga, Danielle R. Nguindex, Mohsin A. Zaidi, L.G. Lehman, Illimar Altosaar and Jeanne Y. Ngogang

Abstract:
Oxidative stress is implied in numerous pathologies, including obesity, type 2 diabetes, atherosclerosis, inflammatory disorders and ageing. Antioxidants are known to neutralise the effects of oxidative stress. Hence, the present study was designed to evaluate the effect of iodine supplementation on the antioxidant status of alloxan monohydrate intoxicated rats. Two groups (A and C) of Wistar rats were kept normal (were not induced oxidative stress), while other two groups (B and D) were induced oxidative stress by alloxan monohydrate (150 mg kg-1) intoxication. Group A and B animals were fed normal rodent diet while group C and D animals’ diet was supplemented with iodine (KI, 25 mg kg-1 diet). The feeding lasted 6 weeks and the animals were sacrificed and the plasma and red blood cells hemolysate prepared from whole blood samples were used for biochemical analysis. Alloxan monohydrate intoxication induced a collapse in the antioxidant system characterized by a significant drop (p<0.05) in antioxidant enzyme activity and ferric reducing antioxidant power as seen in group B animals. However, iodine supplementation tends to prevent this effect with significant increases (p<0.05) in belirubin concentration, Ferric reducing antioxidant power and superoxide dismutase and catalase activities. A significant (p<0.05) reduction in the Thiobarbituric Acid Reactive Substance (TBARs), carbonyl and the thiol functionalities that were originally increased by alloxan monohydrate intoxication, further substantiate the antioxidant status of iodine. Thus, iodine has an antioxidant potential. The antioxidant potential of iodine obtained in this study is informative of the important role iodine plays in the human diet.
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How to cite this article:

Gabriel A. Agbor, Ibrahim Taga, Danielle R. Nguindex, Mohsin A. Zaidi, L.G. Lehman, Illimar Altosaar and Jeanne Y. Ngogang, 2011. Effect of Iodine Supplementation on Antioxidant Status of Normal and Alloxan Monohydrate in Toxicated Rats. International Journal of Pharmacology, 7: 726-731.

DOI: 10.3923/ijp.2011.726.731

URL: https://scialert.net/abstract/?doi=ijp.2011.726.731

 
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