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International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 6 | Page No.: 704-709
DOI: 10.3923/ijp.2011.704.709
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Hypoglycaemic Activity of Tragia tennifolia (Euphorbiaceae) Extract in Rats
G.A. Koffuor, E. Woode and P. Amoateng

The hypoglycaemic effect of the ethanolic Tragia tennifolia Extract (TTE) was studied in Sprague-Dawley rats subjected to Oral Glucose Tolerance Test (OGTT), Fasting Plasma Glucose Test (FPGT) and alloxan-induced diabetes mellitus. Acute toxicity studies were also conducted on Sprague-Dawley rats. TTE (53 mg kg-1, p.o.) significantly (p≤0.01) reduced the peak plasma glucose concentration and the AUC of the OGTT curve, by 47.0 and 44.9%, respectively 1 h after its administration and this was comparable to that produced by glibenclamide (0.14 mg kg-1) and metformin (12.14 mg kg-1). TTE like glibenclamide, significantly (p≤0.01) reduced the fasting plasma glucose by 29.1% after 5 h compared to control groups. The AUC for TTE-treated rats was reduced by 14.8%. In alloxan-induced DM rats, insulin (8.5 unit/kg/day) significantly (p≤0.01) reduced hyperglycaemia by 68.6% whereas TTE, glibenclamide and metformin had no significant effects. Acute toxicity studies showed no evidence of toxicity after an oral administration of TTE (0.1-0.5 g kg-1). These results indicate that TTE may be potentially useful in Non-insulin Dependent Diabetes Mellitus (NIDDM) but not for Insulin Dependent Diabetes Mellitus (IDDM).
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How to cite this article:

G.A. Koffuor, E. Woode and P. Amoateng, 2011. Hypoglycaemic Activity of Tragia tennifolia (Euphorbiaceae) Extract in Rats. International Journal of Pharmacology, 7: 704-709.

DOI: 10.3923/ijp.2011.704.709








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