
	International Journal of Pharmacology
	Year: 2011 \| Volume: 7 \| Issue: 5 \| Page No.: 629-634 DOI: 10.3923/ijp.2011.629.634

Lipolytic Effects of Zingerone in Adipocytes Isolated from Normal Diet-Fed Rats and High Fat Diet-Fed Rats

Pawitra Pulbutr, Klangnapa Thunchomnang, Karakate Lawa, Apiwat Mangkhalathon and Pattarapong Saenubol

Abstract: Zingerone is a non-volatile pungent compound mostly found in ginger which is a herbal medicine used for various purposes. The anti-obesity actions of ginger and zingerone have also been documented. This study was aimed to investigate the effects of zingerone on adipocyte lipolysis in adipocytes isolated from Normal Pellet Diet (NPD)-fed rats and High Fat Diet (HFD)-fed rats. Adipocyte suspensions were prepared from the epididymal fat pads of male Wistar rats by using the collagenase digestion method. The concentrations of Free Fatty Acid (FFA) in the incubation media were used as an index of adipocyte lipolysis. Zingerone at the concentration of 1,000 μM significantly increased both basal lipolysis and isoprenaline (0.l μM)-induced lipolysis in adipocytes derived from the NPD-fed rats with the FFA concentrations of 682.92±37.00 μM mL^-1 Packed Cell Volume (PCV)/ h and 1,361.51±62.90 μM mL^-1 PCV/ h, respectively (p<0.05; n = 4). In adipocytes derived from the HFD-fed rats, zingerone at any concentration tested had no effect on the basal lipolysis. Zingerone only at the concentration of 100 μM significantly stimulated the isoprenaline-induced lipolysis with the FFA concentration of 1,383.88±36.73 μM mL^-1 PCV/ h (p<0.05; n = 4) in adipocytes derived from the HFD-fed rats. In conclusion, zingerone appeared to produce less lipolytic actions in adipocytes derived from the HFD-fed rats. The reason for the lower lipolytic response to zingerone in HFD-derived adipocytes should be investigated further, especially in the molecular aspects.

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How to cite this article:

Pawitra Pulbutr, Klangnapa Thunchomnang, Karakate Lawa, Apiwat Mangkhalathon and Pattarapong Saenubol, 2011. Lipolytic Effects of Zingerone in Adipocytes Isolated from Normal Diet-Fed Rats and High Fat Diet-Fed Rats. International Journal of Pharmacology, 7: 629-634.

DOI: 10.3923/ijp.2011.629.634

URL: https://scialert.net/abstract/?doi=ijp.2011.629.634

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