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International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 4 | Page No.: 504-509
DOI: 10.3923/ijp.2011.504.509
Study of Hepatoprotective Activity of Solanum nigrum and Cichorium intybus
K.R. Subash, K.S. Ramesh, Binoy Vargheese Charian, Francis Britto, N. Jagan Rao and S. Vijaykumar

Abstract:
The study was conducted to evaluate the hepatoprotective activity of Solanum nigrum and Cichorium intybus. Hepatotoxicity was induced in albino rats with 1:1(v/v) mixture of CCL4 in olive oil, administered at the dose of 1.5 mg kg-1 i.p on 7th day. The extract of Solanum nigrum and Cichorium intybus were administered to the experimental rats. The hepatoprotective effect of these extracts was evaluated by the assay of serum protein, Serum bilirubin and serum enzymes like Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Markers for oxidative stress like Glutathione (GSH), Superoxide Dismutase (SOD), Lipid Peroxidase (LPO) and histopathological studies of liver. In the groups where hepatic injury induced by CCL4 and extract were given simultaneously, the toxic effect of CCL4 was controlled significantly (<0.05) by maintenance of structural integrity of hepatocyte cell membrane and normalisation of functional status of liver. Histology of liver sections from Solanum nigrum and Cichorium intybus + CCL4 treated rats revealed moderate centrilobular hepatocytes degeneration, few areas of congestion with mild fatty changes. The extract of Solanum nigrum and Cichorium intybus possess significant hepatoprotective activity in comparison to standard drug Silymarin.
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How to cite this article:

K.R. Subash, K.S. Ramesh, Binoy Vargheese Charian, Francis Britto, N. Jagan Rao and S. Vijaykumar, 2011. Study of Hepatoprotective Activity of Solanum nigrum and Cichorium intybus. International Journal of Pharmacology, 7: 504-509.

DOI: 10.3923/ijp.2011.504.509

URL: https://scialert.net/abstract/?doi=ijp.2011.504.509

COMMENTS
22 April, 2012
praveena:
methodology explained well and easily reproducible
 
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