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International Journal of Pharmacology

Year: 2011 | Volume: 7 | Issue: 4 | Page No.: 504-509
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Authors

K.R. Subash

K.S. Ramesh

Binoy Vargheese Charian

Francis Britto

N. Jagan Rao

S. Vijaykumar

Keywords

The study was conducted to evaluate the hepatoprotective activity of Solanum nigrum and Cichorium intybus. Hepatotoxicity was induced in albino rats with 1:1(v/v) mixture of CCL4 in olive oil, administered at the dose of 1.5 mg kg-1 i.p on 7th day. The extract of Solanum nigrum and Cichorium intybus were administered to the experimental rats. The hepatoprotective effect of these extracts was evaluated by the assay of serum protein, Serum bilirubin and serum enzymes like Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Markers for oxidative stress like Glutathione (GSH), Superoxide Dismutase (SOD), Lipid Peroxidase (LPO) and histopathological studies of liver. In the groups where hepatic injury induced by CCL4 and extract were given simultaneously, the toxic effect of CCL4 was controlled significantly (<0.05) by maintenance of structural integrity of hepatocyte cell membrane and normalisation of functional status of liver. Histology of liver sections from Solanum nigrum and Cichorium intybus + CCL4 treated rats revealed moderate centrilobular hepatocytes degeneration, few areas of congestion with mild fatty changes. The extract of Solanum nigrum and Cichorium intybus possess significant hepatoprotective activity in comparison to standard drug Silymarin.
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Comments

praveena Reply

methodology explained well and easily reproducible

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