• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Pharmacology
  2. Vol 7 (4), 2011
  3. 498-503
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Pharmacology

Year: 2011 | Volume: 7 | Issue: 4 | Page No.: 498-503
DOI: 10.3923/ijp.2011.498.503

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 778

Search


Authors


V. Bala

Country: Bangladesh

A. Debnath

Country: Bangladesh

A.K. Shill

Country: Bangladesh

U. Bose

Country: Bangladesh

Keywords


  • Mucuna prurient Linn
  • carrageenin
  • cotton pellet granuloma
  • furosemide
  • disc diffusion
  • ethanolic extract
Research Article

Anti-Inflammatory, Diuretic and Antibacterial Activities of Aerial Parts of Mucuna pruriens Linn.

V. Bala, A. Debnath, A.K. Shill and U. Bose
The ethanolic extract of the dried aerial parts of Mucuna pruriens Linn. (Fabaceae) was investigated for its possible anti-inflammatory, diuretic and antibacterial activities in animal models. Anti-inflammatory activity was tested using carrageenin induced rat paw edema model and cotton pellet implantation method in rat. Diuretic activity was measured by the comparison of control group, standard drug group (furosemide) at a dose of 0.5 mg kg-1 and the sample extracts 200 and 400 mg kg-1, respectively. The antibacterial property was studied by the disc diffusion method using extract 200 mg disc-1. The extracts significantly (p<0.001) reduced carrageenin induced paw edema in rats. Cotton pellet implantation model for antiinflammatory activity, the extract showed a significant reduction in the weight of the cotton pellet in test animal compared to control (p<0.001). At the doses of 200 and 400 mg kg-1, the extract exhibited 24.59 and 33.41% reduction of the weight of the cotton pellets. Diuretic activity was proved by the electrolyte loss ratio (Na+/K+ excretion ratio was 1.48 and 1.45 at the doses of 200 and 400 mg kg-1, respectively) as that of the standard diuretic furosemide (1.47). The extracts also showed the antibacterial activity against eight species of bacteria. The results obtained shows that the extracts of Mucuna pruriens Linn. has anti-inflammatory, diuretic and antibacterial properties. This finding provides a basis for the traditional use of the plant material.
PDF Fulltext XML References Citation

How to cite this article

V. Bala, A. Debnath, A.K. Shill and U. Bose, 2011. Anti-Inflammatory, Diuretic and Antibacterial Activities of Aerial Parts of Mucuna pruriens Linn. International Journal of Pharmacology, 7: 498-503.

DOI: 10.3923/ijp.2011.498.503

URL: https://scialert.net/abstract/?doi=ijp.2011.498.503

Related Articles

Evaluation of Diuretic Effect of the Hot Water Extract of Standardized Tragia involucrata Linn., in Rats
Anti-inflammatory and Antioxidant Activities of a Fraction I1 of Male Inflorescences of Borassus aethiopum Mart (Arecaceae)
Phytopharmacology of Antiophidian Botanicals: A Review

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved