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International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 4 | Page No.: 455-462
DOI: 10.3923/ijp.2011.455.462
 
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Pleurotus nebrodensis Ameliorates Atherogenic Lipid and Histological Function in Hypercholesterolemic Rats

N. Alam, K.N. Yoon, J.S. Lee, M.W. Lee and T.S. Lee

Abstract:
Pleurotus nebrodensis is a popular edible mushroom has been widely used for nutritional and medicinal purposes. The effects of dietary P. nebrodensis fruiting bodies on plasma and feces biochemical and on the liver histological status were estimated in hypercholesterolemic rats. Six-week old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Feeding of a diet containing a 5% P. nebrodensis fruiting bodies to hypercholesterolemic rats reduced plasma total cholesterol, triglyceride, low-density lipoprotein, total lipid, phospholipids and LDL/HDL ratio by 31.01, 47.71, 62.50, 31.91, 24.65 and 53.06%, respectively. Feeding mushroom also significantly reduced body weight in hypercholesterolemic rats. Nevertheless, it had no adverse effects on plasma albumin, total bilirubin, direct bilirubin, creatinin, blood urea nitrogen, uric acid, glucose, total protein, calcium, sodium, potassium, chloride, inorganic phosphate, magnesium, or enzyme profiles. Feeding mushroom increased total lipid and cholesterol excretion in feces. The plasma lipoprotein fraction, separated by agarose gel electrophoresis, indicated that P. nebrodensis significantly reduced plasma β and pre-β-lipoprotein, while increased α-lipoprotein. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red-O staining showed normal findings for mushroom-fed hypercholesterolemic rat. The present study suggests that a 5% P. nebrodensis diet supplement provided health benefits by acting on the atherogenic lipid profile in hypercholesterolemic condition.
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How to cite this article:

N. Alam, K.N. Yoon, J.S. Lee, M.W. Lee and T.S. Lee, 2011. Pleurotus nebrodensis Ameliorates Atherogenic Lipid and Histological Function in Hypercholesterolemic Rats. International Journal of Pharmacology, 7: 455-462.

DOI: 10.3923/ijp.2011.455.462

URL: https://scialert.net/abstract/?doi=ijp.2011.455.462

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