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International Journal of Pharmacology

Year: 2011 | Volume: 7 | Issue: 4 | Page No.: 455-462
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Authors

N. Alam

K.N. Yoon

J.S. Lee

M.W. Lee

T.S. Lee

Keywords

Research Article

Pleurotus nebrodensis Ameliorates Atherogenic Lipid and Histological Function in Hypercholesterolemic Rats

N. Alam, K.N. Yoon, J.S. Lee, M.W. Lee and T.S. Lee
Pleurotus nebrodensis is a popular edible mushroom has been widely used for nutritional and medicinal purposes. The effects of dietary P. nebrodensis fruiting bodies on plasma and feces biochemical and on the liver histological status were estimated in hypercholesterolemic rats. Six-week old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Feeding of a diet containing a 5% P. nebrodensis fruiting bodies to hypercholesterolemic rats reduced plasma total cholesterol, triglyceride, low-density lipoprotein, total lipid, phospholipids and LDL/HDL ratio by 31.01, 47.71, 62.50, 31.91, 24.65 and 53.06%, respectively. Feeding mushroom also significantly reduced body weight in hypercholesterolemic rats. Nevertheless, it had no adverse effects on plasma albumin, total bilirubin, direct bilirubin, creatinin, blood urea nitrogen, uric acid, glucose, total protein, calcium, sodium, potassium, chloride, inorganic phosphate, magnesium, or enzyme profiles. Feeding mushroom increased total lipid and cholesterol excretion in feces. The plasma lipoprotein fraction, separated by agarose gel electrophoresis, indicated that P. nebrodensis significantly reduced plasma β and pre-β-lipoprotein, while increased α-lipoprotein. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red-O staining showed normal findings for mushroom-fed hypercholesterolemic rat. The present study suggests that a 5% P. nebrodensis diet supplement provided health benefits by acting on the atherogenic lipid profile in hypercholesterolemic condition.
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