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International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 2 | Page No.: 273-277
DOI: 10.3923/ijp.2011.273.277
 
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Action of Ropivacaine as a Surface Anaesthetic on the Cornea of Rabbits

N. Chandrasekhar, T. Jayasree, M. Vinay, Rohit Dixit, V.S. Manohar and N. Jagan Rao

Abstract:
The aim of the present study was to investigate the role of Ropivacaine as a surface anesthetic on the cornea of rabbits. Twenty Albino rabbits (weighing 2.5 to 3.0 kg of either sex) were randomly allocated to 2 treatment groups-Group I and II. The upper and lower eye lashes of all the rabbits were carefully clipped off. The conjunctival sac of right eye was held open to form a pocket. Into these pockets, animals in Group I were delivered 1 drop (containing 535.71 μg of Ropivacaine) of the standard solution of Ropivacaine and those in Group II were delivered 2 drops (containing 1071.42 μg of Ropivacaine) of the same solution. The left eye served as the control. The corneal reflex was elicited by touching the cornea from the side using a cotton wisp. The time between the disappearance and reappearance of corneal reflex (duration of action) was registered. Statistical analysis revealed highly significant differences between group I and group II (p<0.001). The mean onset of action for group I was 10 min and for group II was 5 min. The mean duration of action for group I was 29±4.595 and for group II was 48±5.869. Ropivacaine can be used as surface anaesthetic as Proparcaine and Tetracaine for removal of foreign bodies and other clinical conditions in ophthalmology.
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How to cite this article:

N. Chandrasekhar, T. Jayasree, M. Vinay, Rohit Dixit, V.S. Manohar and N. Jagan Rao, 2011. Action of Ropivacaine as a Surface Anaesthetic on the Cornea of Rabbits. International Journal of Pharmacology, 7: 273-277.

DOI: 10.3923/ijp.2011.273.277

URL: https://scialert.net/abstract/?doi=ijp.2011.273.277

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