The diseases associated to liver, heart, blood, brain, kidneys, spleen, pancreas, nerves, hormones, fluids and electrolytes, virus, bacteria, protozoa, fungi etc. are paying much attention and numerous research work is been done in respective areas, worldwide metabolic disorders are need to pay an attention. Problems related to liver such as acute or chronic inflammation, toxin-/drug-induced hepatitis, cirrhosis and hepatitis are very common nowadays due to our exposure to different environmental pollutants like chemicals, toxins, viruses etc. For centuries, many herbal drugs and formulations have been used as natural remedies for the prevention and/or treatment of liver diseases and have been popularized world over by leading pharmaceuticals. Due to insufficient scientific-based pharmacological data, most of the herbal formulations cannot be recommended for the treatment of liver diseases. In this review article, an attempt has been made to focus a brief view on few herbal hepatoprotective leads that may be useful to the health professionals, scientists and scholars working the field of pharmacology and therapeutics to develop evidence-based alternative medicine to cure different kinds of liver dysfunctions.