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International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 2 | Page No.: 161-170
DOI: 10.3923/ijp.2011.161.170
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A Systematic Review of Efficacy and Safety of Urtica dioica in the Treatment of Diabetes

Avin Mehri, Shirin Hasani-Ranjbar, Bagher Larijani and Mohammad Abdollahi

This review focuses on the efficacy and safety of Urtica dioica which has been utilized in traditional medicine for management of diabetes. All relevant databases including Pubmed, Google Scholar, Web of Science, Scopus, Iranmedex and MD Consult were searched for the terms diabetes mellitus and Urtica dioica without limitation up to 15th September 2010. All the animal studies with the outcome of change in blood glucose or other relevant complications of diabetes and all available abstracts were included. Review articles and letters to the editor were excluded. Search of databases resulted in 724 articles which 87 were potentially relevant studies on Urtica dioica and diabetes. On the basis of inclusion/exclusion criteria, 21 studies were finally included. One human and 20 animal studies were reviewed for the efficacy of Urtica dioica. Most of these studies showed significant decrease in blood glucose and complications of diabetes by use of Urtica dioica. Urtica dioica can affect both pancreatic and extra pancreatic pathways. Available evidences suggest that Urtica dioica can be used to treat diabetes and its long-term complications. Of course, further experiments would help determine exact mechanisms of action, effects and side effects of this herbal medicine.
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  •    South Asian Herbal Plants as Anti-hypertensive Agents- A Review
  •    Traditional Medicinal Herbs for the Management of Diabetes and its Complications: An Evidence-Based Review
  •    Iranian Medicinal Plants for Diabetes Mellitus: A Systematic Review
  •    The Mechanisms of Positive Effects of Melatonin in Dyslipidemia: A Systematic Review of Animal and Human Studies
  •    Effects of the Mixture of Melissa officinalis L., Cinnamomum zeylanicum and Urtica dioica on Hepatic Enzymes Activity in Patients with Nonalcoholic Fatty Liver Disease
  •    An Update on Pharmacology of Satureja Species; From Antioxidant, Antimicrobial, Antidiabetes and Anti-hyperlipidemic to Reproductive Stimulation
  •    Effect of Urtica dioica on Morphometric Indices of Kidney in Streptozotocin Diabetic Rats-A Stereological Study
How to cite this article:

Avin Mehri, Shirin Hasani-Ranjbar, Bagher Larijani and Mohammad Abdollahi, 2011. A Systematic Review of Efficacy and Safety of Urtica dioica in the Treatment of Diabetes. International Journal of Pharmacology, 7: 161-170.

DOI: 10.3923/ijp.2011.161.170






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