Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 6 | Page No.: 921-925
DOI: 10.3923/ijp.2010.921.925
Antiplasmodial Activity and Cytotoxicity of Semi Purified Fractions from Zanthoxylum zanthoxyloïdes Lam. Bark of Trunk
A. Gansane, S. Sanon, P.L. Ouattara, S. Hutter, E. Ollivier, N. Azas, A. Traore, A.S. Traore, I.P. Guissou, I. Nebie and B.S. Sirima

Abstract:
The aim of the study is to investigate through traditional medicinal plants the possibility for discovery and development of new active and safe antimalarial drugs. For ecological reasons, bark of trunk of Zanthoxylum zanthoxyloides instead to roots was used by traditional healers in Burkina Faso to treat malaria or fever and recent study showed that crude alkaloid extract from the bark of trunk displayed good antiplasmodial activity. The bio-guided chromatographic fractionation of this crude alkaloid extract with solvents yielded 11 semi purified fractions which were tested for their antiplasmodial activity and cytotoxicity, respectively against Plasmodium falciparum W2 strains and K562S cells maintained in continuous culture and using flow cytometer. Non polar fractions 2, 3 and 4 displayed good antiplasmodial activity with IC50 ranging from 1.91 to 4.32 μg mL-1 and little toxicity with selectivity index ranging from 3.03 to 6.15. These data allow further investigations in terms of purification, isolation and development of new antiplasmodial compounds from these semi purified fractions and development of improved phytomedicine.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Cytotoxcity and in vivo Antimalarial Activity of Aqueous Whole Plant Extract of Munronia pinnata (Wall.) Theob. (Meliaceae) in Mice
  •    In vitro Cytotoxic Evaluation of Hugonia mystax Linn. Leaf and Stem Bark Extracts
  •    Evaluation of the Antimicrobial Activity of Zanthoxylum zanthoxyloides Root Bark Extracts
  •    A Review on the Recent Advances in Pharmacological Studies on Medicinal Plants; Animal Studies are Done but Clinical Studies Needs Completing
How to cite this article:

A. Gansane, S. Sanon, P.L. Ouattara, S. Hutter, E. Ollivier, N. Azas, A. Traore, A.S. Traore, I.P. Guissou, I. Nebie and B.S. Sirima, 2010. Antiplasmodial Activity and Cytotoxicity of Semi Purified Fractions from Zanthoxylum zanthoxyloïdes Lam. Bark of Trunk. International Journal of Pharmacology, 6: 921-925.

DOI: 10.3923/ijp.2010.921.925

URL: https://scialert.net/abstract/?doi=ijp.2010.921.925

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom