Submit Manuscript

International Journal of Pharmacology

Year: 2010 | Volume: 6 | Issue: 1 | Page No.: 68-71
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 657

Search

Authors

D.N. Patil

A.R. Kulkarni

B.S. Patil

Keywords

Research Article

Fruit Gum of Aegle marmelos as Pharmaceutical Aid

D.N. Patil, A.R. Kulkarni and B.S. Patil
In the present study have formulated the oral tablets of paracetamol by using Aegle marmelos fruit gum as a binder. The four different tablet formulations were prepared by wet granulation method. The binder concentrations used in the formulation were 2, 4, 6 and 8% w/v of A. marmelos fruit gum, tablets were subjected for evaluation of hardness, friability, drug content uniformity. Preliminary evaluation of granules showed that, 0.71 to 0.77 mm granule size, 29.20 to 30.10° angles of repose and 22.1 to 12.7% fines. Hardness was found in the range of 7.1 to 7.4 kg cm-2, the percent friability was in the range of 1.50 to 0.75%. The tablet showed 97.46 to 98.96% of labeled amount of paracetamol indicating uniformity in drug content, 8 to 18 min disintegration time and more than 90% dissolution in 75 min. Tablets at 6% w/w binder concentration showed more optimum results as tablet binder. The Aegle marmelos gum was found to be useful for the preparation of uncoated tablet dosage form.
PDF Fulltext XML References Citation

Leave a Comment

Your email address will not be published. Required fields are marked *