Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 5 | Page No.: 658-663
DOI: 10.3923/ijp.2010.658.663
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Hepatoprotective Activity on Vitex negundo Linn. (Verbenaceae) by using Wistar Albino Rats in Ibuprofen Induced Model

R. Mahalakshmi, P. Rajesh, N. Ramesh, V. Balasubramanian and V. Rajesh Kannan

Abstract:
The present study was intended to evaluate the hepatoprotective activity on ethanolic extract of leaves of Vitex negundo was determined by using Wistar Albino rats in male sex. The V. negundo Linn. is a natural plant product, in it’s the leaves are used with the added advantage to revert Ibuprofen induced hepatotoxicity. Oral administration of ethanol extract of V. negundo (100 and 300 mg) produced a significant and dose dependent inhibition to the acute hepatotoxic induced rats and various parameters were analyzed, when compared with negative control V. negundo showed that the significant activity in 300 mg/kg/b.wt. They exhibited a significant inhibition of hepatic toxicity by using various marker enzymes and the histopathological analysis. The inhibitory effect of the V. negundo on hepatotoxicity was compared to that of positive control group. The various parameters such glucose, protein, triglycerides, bilirubin, urea, creatinine, ALP, ACP, SGPT, SGOT and histopathological parameters was measured by dissection the rats. A significant index and values were observed in the acute assays; an effective significant alteration in all biochemical and histopathological sections was observed. From these results, concluded that the V. negundo having the potential effectiveness at the dose of 300 mg/kg/b.wt., (p<0.01) significance in a dose dependent manner. These results suggest that leaves of V. negundo having the hepatoprotective activity, which support the hepatic cells protection.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Plant as a Source of Natural Antiviral Agents
  •    A Review on the Recent Advances in Pharmacological Studies on Medicinal Plants; Animal Studies are Done but Clinical Studies Needs Completing
How to cite this article:

R. Mahalakshmi, P. Rajesh, N. Ramesh, V. Balasubramanian and V. Rajesh Kannan, 2010. Hepatoprotective Activity on Vitex negundo Linn. (Verbenaceae) by using Wistar Albino Rats in Ibuprofen Induced Model. International Journal of Pharmacology, 6: 658-663.

DOI: 10.3923/ijp.2010.658.663

URL: https://scialert.net/abstract/?doi=ijp.2010.658.663

COMMENTS
01 July, 2010
Balamurugan :
The article is very nice for my further research work.

I am getting useful information about the toxicity in this study.

Thanking you.
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

Curve Bottom