Subscribe Now Subscribe Today
Science Alert
Curve Top
International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 5 | Page No.: 616-623
DOI: 10.3923/ijp.2010.616.623
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

The Role of Medicinal Herbs in Angiogenesis Related Diseases

H.B. Sahib, N.A.H. Harchan, S.A.M. Atraqchi and A.A. Abbas

Angiogenesis, the development of new blood vessels from existing one, is essential in normal growth processes. Uncontrolled angiogenesis is a main contributor to a number of disease states such as asthma, AIDS, bacterial infections, autoimmune disease, cirrhosis, diabetes, obesity, multiple sclerosis and endometriosis, Angiogenesis also considered a key step in tumour growth, invasion and metastasis. Angiogenesis is required for suitable nourishment and removal of metabolic wastes from tumour sites. Therefore, modulation of angiogenesis is considered as therapeutic strategies of great importance for human health. Numerous bioactive plant extracts are recently tested for their anti-angiogenic potential. Among the most frequently studied are plants rich with polyphenols and terpens present in fruits, vegetables and other plants which have high antioxidant compounds. Plant polyphenols inhibit angiogenesis and metastasis through regulation of multiple signaling pathways. Specifically, flavonoids regulate expression of Vascular Endothelial Growth Factor (VEGF), matrix metalloproteinase (MMPs), Epidermal Growth Factor Receptor (EGFR) and inhibit nuclear factor _B (NF_B), phosphatidylinositol-3-kinase (PI3-K/Akt) and Extra Cellular Signal-Regulated Kinases 1 and 2 (ERK1/2) signaling pathways, thereby causing strong anti-angiogenic effects. This review focuses on the antiangiogenic plants.
PDF Fulltext XML References Citation Report Citation
  •    Anti-angiogenic and Antioxidant Activity of Iraqi Cyperus rotundus Ethanol Extract
  •    Phytonutrients and Nutraceuticals in Vegetables and Their Multi-dimensional Medicinal and Health Benefits for Humans and Their Companion Animals: A Review
  •    AT1 Receptors Activation Enhances the Expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 Melanoma Cells
  •    Orthosiphon stamineus Benth. Methanolic Extract Enhances the Anti-Proliferative Effects of Tamoxifen on Human Hormone Dependent Breast Cancer
How to cite this article:

H.B. Sahib, N.A.H. Harchan, S.A.M. Atraqchi and A.A. Abbas, 2010. The Role of Medicinal Herbs in Angiogenesis Related Diseases. International Journal of Pharmacology, 6: 616-623.

DOI: 10.3923/ijp.2010.616.623






Curve Bottom