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International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 4 | Page No.: 400-406
DOI: 10.3923/ijp.2010.400.406
Antioxidant and Hypolipidemic Effect of Caralluma adscendens Roxb. in Alloxanized Diabetic Rats
A.U. Tatiya, A.S. Kulkarni, S.J. Surana and N.D. Bari

Abstract:
In the present study, various extracts of Caralluma adscendens were evaluated by alloxan induced (150 mg kg-1 i.p.) diabetic rats and oral glucose tolerance test. Fasting blood glucose estimation was done at 0, 30, 90 and 150 min after treatment. Lipid profile and body weight measurements were done on day 0, 7, 14 of the study. Antioxidant effects were also evaluated using Diphenyl-1-Picrylhydrazyl (DPPH), in vitro lipid peroxidation and reductive ability methods. The treatment showed significant lowering of blood glucose in the treated diabetic rat from 273.1±4.01 to 82.1±1.4* mg dL-1 by butanolic extract of C. adscendens, 150 min after the treatment (*p<0.01). It also showed significant decrease in total cholesterol, LDL, triglyceride and TC /HDL and an increase in HDL in the treated diabetic animal group. Glucose tolerance was also improved. In vitro antioxidant activity showed that the butanolic extract exhibited potent free radical scavenging effects. All the results were compared with standard drug Glibenclamide.
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How to cite this article:

A.U. Tatiya, A.S. Kulkarni, S.J. Surana and N.D. Bari, 2010. Antioxidant and Hypolipidemic Effect of Caralluma adscendens Roxb. in Alloxanized Diabetic Rats. International Journal of Pharmacology, 6: 400-406.

DOI: 10.3923/ijp.2010.400.406

URL: https://scialert.net/abstract/?doi=ijp.2010.400.406

 
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