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International Journal of Pharmacology
  Year: 2010 | Volume: 6 | Issue: 4 | Page No.: 379-385
DOI: 10.3923/ijp.2010.379.385
Endocrine Function and Duration Time of Estrous Cyclicity of the Ovariectomized Recipiented Neonate Vitrified Ovarian Grafts Mice after Treatment with Melatonin
Hemadi Masoud and Saki Ghasem

Abstract:
The effect of melatonin on estrous period of ovariectomized mice which received neonate vitrified ovarian grafts was studied. Vitrified ovaries from neonate F1 hybrid mice, candidates for transplantation to treated or non-treated groups, were thawed under standard conditions with or without the addition of 100 μM melatonin, respectively. Following transplantation, melatonin (20 mg/kg/day) or saline solution was injected i.p., to treated and non-treated groups, respectively. Melatonin, gonadothropins and steroids concentrations, together with vaginal cytology to monitor estrogenic activity of ovariectomized recipient mice were carried out. Studies showed that the restoration of fertile estrous was similar between treated and control groups. However, the estrous cyclicity duration as well as estrous time of fertile period in the treated group was shorter than non-treated group. Plasma LH and FSH levels were higher in the ovariectomized host at before restoring ovary graft cyclicity than intact mice. However, the melatonin administration reduced these high levels into nearly similar concentrations to those in intact mice. The correlation coefficients between gonadothropins and melatonin concentrations at the different stages of the estrous cycle were significantly different from zero. indeed, progesterone secretion in spite of estradiol was adversely affected by melatonin treatment. Meanwhile, the correlation coefficients were significantly different from zero. These results suggest that melatonin could be having positive effects on the deficient activity of hypothalamic-pituitary-ovarian axis especially on the progesterone drive of the recipient.
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How to cite this article:

Hemadi Masoud and Saki Ghasem, 2010. Endocrine Function and Duration Time of Estrous Cyclicity of the Ovariectomized Recipiented Neonate Vitrified Ovarian Grafts Mice after Treatment with Melatonin. International Journal of Pharmacology, 6: 379-385.

DOI: 10.3923/ijp.2010.379.385

URL: https://scialert.net/abstract/?doi=ijp.2010.379.385

 
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